Prava Rout Bidyut, Behera Birasen, Kumar Sahu Kundan, Praharaj Ira, Otta Sarita
Ph.D. Scholar in Biotechnology, IMS & SUM Hospital, Bhubaneswar, Odisha, India.
Professor & Head (Microbiology), IMS & SUM Hospital, Bhubaneswar, Odisha, India.
Med J Armed Forces India. 2023 Sep-Oct;79(5):516-525. doi: 10.1016/j.mjafi.2023.06.006. Epub 2023 Aug 8.
Rising prevalence of antibiotic resistance and the unavailability of newer drugs to tackle this menace is one of the major hindrances to the goal of health and well-being set up by the General Assembly of the United Nations. The genes responsible for this resistance are often disseminated from hospitals to different environmental sources. In 2015, for the first time, resistance to Colistin was detected caused by chromosomal genetic mutations. Later, plasmid-mediated colistin resistance (MCR-1 to MCR-10) was detected, first from China and then from various other countries. As per Clinical and Laboratory Standards Institute (CLSI), commonly available diffusion techniques cannot detect colistin resistance appropriately. Even commercial susceptibility systems fail in this regard. Keeping in mind the importance of surveillance of colistin-resistant bugs, we present an update on the prevalence, mechanism of resistance, and detection.
抗生素耐药性的日益普遍以及缺乏应对这一威胁的新型药物，是联合国大会设定的健康与福祉目标的主要障碍之一。导致这种耐药性的基因常常从医院传播到不同的环境源。2015年，首次检测到由染色体基因突变引起的对黏菌素的耐药性。后来，检测到质粒介导的黏菌素耐药性（MCR - 1至MCR - 10），首先在中国，然后在其他各个国家。根据临床和实验室标准协会（CLSI），常用的扩散技术无法适当地检测黏菌素耐药性。即使是商业药敏系统在这方面也存在不足。考虑到监测耐黏菌素细菌的重要性，我们提供了关于其流行情况、耐药机制和检测方法的最新信息。
