Walden Kylie E, Moon Jessica M, Hagele Anthony M, Allen Leah E, Gaige Connor J, Krieger Joesi M, Jäger Ralf, Mumford Petey W, Pane Marco, Kerksick Chad M
Exercise and Performance Nutrition Laboratory, Department of Kinesiology, College of Science, Technology, and Health, Lindenwood University, Saint Charles, MO, United States.
Increnovo LLC, Milwaukee, WI, United States.
Front Nutr. 2023 Aug 31;10:1219313. doi: 10.3389/fnut.2023.1219313. eCollection 2023.
To examine the efficacy of supplementing with a multi-strain probiotic (MSP) on changes associated with mood, anxiety, and neurotransmitter levels.
In a randomized, double-blind, placebo-controlled fashion, 70 healthy men and women (31.0 ± 9.5 years, 173.0 ± 10.4 cm, 73.9 ± 13.8 kg, 24.6 ± 3.5 kg/m) supplemented with a single capsule of MSP (a total daily dose of 4 × 10 colony forming units [CFU] comprised of a 1 × 10 CFU dose from each of the following strains: LF16, LR06, LP01, and 04, Probiotical S.p.A., Novara, Italy) or a maltodextrin placebo (PLA). After 0, 2, 4, and 6 weeks of supplementation and 3 weeks after ceasing supplementation, study participants completed the Beck Depression Inventory (BDI-II), State-Trait Anxiety Inventory (STAI), and Leiden Index of Depression Sensitivity (LEIDS-R) questionnaires and had plasma concentrations of cortisol, dopamine, serotonin, and C-reactive protein determined.
BDI, STAI, and total LEIDS-R scores were reduced from baseline ( < 0.05) with MSP supplementation after 4 and 6 weeks of supplementation and 3 weeks after supplementation while no changes ( > 0.05) were reported in PLA. When compared to PLA, MSP scores for state anxiety, trait anxiety, and LEIDS-R (hopeless, aggression, rumination, and total score) were significantly lower ( < 0.05) after supplementation. Plasma serotonin concentrations in MSP were increased from baseline after 6 weeks of supplementation and 3 weeks after ceasing supplementation. No changes ( > 0.05) in plasma dopamine, C-reactive protein, or cortisol concentrations were observed between groups.
MSP supplementation resulted in widespread improvements in several questionnaires evaluating mood, anxiety, and depression in young, healthy men and women. MSP supplementation increased serotonin increased after 6 weeks of MSP supplementation with no change in dopamine, C-reactive protein, or cortisol.
https://classic.clinicaltrials.gov/ct2/show/NCT05343533, NCT05343533.
研究补充多菌株益生菌（MSP）对情绪、焦虑及神经递质水平相关变化的疗效。
采用随机、双盲、安慰剂对照方式，70名健康男性和女性（年龄31.0±9.5岁，身高173.0±10.4厘米，体重73.9±13.8千克，体重指数24.6±3.5千克/平方米）补充一粒MSP胶囊（每日总剂量为4×10菌落形成单位[CFU]，由以下每种菌株各1×10 CFU剂量组成：LF16、LR06、LP01和04，意大利诺瓦拉的Probiotical S.p.A.公司生产）或麦芽糊精安慰剂（PLA）。在补充0、2、4和6周后以及停止补充3周后，研究参与者完成贝克抑郁量表（BDI-II）、状态-特质焦虑量表（STAI）和莱顿抑郁敏感性指数（LEIDS-R）问卷，并测定血浆皮质醇、多巴胺、血清素和C反应蛋白浓度。
补充MSP 4周和6周后以及补充后3周，BDI、STAI和总LEIDS-R评分较基线降低（P<0.05），而PLA组无变化（P>0.05）。与PLA相比，补充MSP后状态焦虑、特质焦虑和LEIDS-R（绝望、攻击性、反刍和总分）评分显著更低（P<0.05）。补充MSP 6周后及停止补充3周后，MSP组血浆血清素浓度较基线升高。两组间血浆多巴胺、C反应蛋白或皮质醇浓度无变化（P>0.05）。
补充MSP使评估年轻健康男性和女性情绪、焦虑和抑郁的多项问卷结果普遍改善。补充MSP 6周后血清素增加，多巴胺、C反应蛋白或皮质醇无变化。
https://classic.clinicaltrials.gov/ct2/show/NCT05343533，NCT05343533
