Norte-Muñoz María, García-Bernal David, García-Ayuso Diego, Vidal-Sanz Manuel, Agudo-Barriuso Marta
Grupo de Investigación Oftalmología Experimental, Departamento de Oftalmología, Optometría, Otorrinolaringología y Anatomía Patológica, Facultad de Medicina, Universidad de Murcia, Instituto Murciano de Investigación Biosanitaria (IMIB), Campus de Ciencias de la Salud, 30120 Murcia, Spain.
Grupo de Investigación Trasplante Hematopoyético y Terapia celular, Departamento de Bioquímica e Inmunología. Facultad de Medicina, Universidad de Murcia, Instituto Murciano de Investigación Biosanitaria (IMIB), Campus de Ciencias de la Salud, 30120 Murcia, Spain.
Neural Regen Res. 2024 Mar;19(3):542-547. doi: 10.4103/1673-5374.380876.
Advanced mesenchymal stromal cell-based therapies for neurodegenerative diseases are widely investigated in preclinical models. Mesenchymal stromal cells are well positioned as therapeutics because they address the underlying mechanisms of neurodegeneration, namely trophic factor deprivation and neuroinflammation. Most studies have focused on the beneficial effects of mesenchymal stromal cell transplantation on neuronal survival or functional improvement. However, little attention has been paid to the interaction between mesenchymal stromal cells and the host immune system due to the immunomodulatory properties of mesenchymal stromal cells and the long-held belief of the immunoprivileged status of the central nervous system. Here, we review the crosstalk between mesenchymal stromal cells and the immune system in general and in the context of the central nervous system, focusing on recent work in the retina and the importance of the type of transplantation.
基于高级间充质基质细胞的神经退行性疾病治疗方法在临床前模型中得到了广泛研究。间充质基质细胞作为治疗手段具有良好的定位，因为它们针对神经退行性变的潜在机制，即营养因子缺乏和神经炎症。大多数研究集中在间充质基质细胞移植对神经元存活或功能改善的有益作用上。然而，由于间充质基质细胞的免疫调节特性以及长期以来认为中枢神经系统具有免疫豁免地位，人们对间充质基质细胞与宿主免疫系统之间的相互作用关注较少。在这里，我们综述了间充质基质细胞与免疫系统之间的一般相互作用以及在中枢神经系统背景下的相互作用，重点关注视网膜的最新研究工作以及移植类型的重要性。
