Sega S, Jager F, Kiauta T
Department of Neurology, University Medical Centre, Ljubljana, Slovenia.
Clin Auton Res. 1993 Jun;3(3):175-82. doi: 10.1007/BF01826230.
Determination of whether results of cardiovascular reflex tests and spectral analysis of heart rate variability are age dependent and whether there is correlation between results of both, cardiovascular reflex tests (the Valsalva manoeuvre, deep breathing test, handgrip test, cold face stimulus test, orthostatic test) and spectral analysis of heart rate variability were performed on 83 healthy volunteers of both genders, aged 21 to 70 years. We found that results of all heart rate based tests and results of spectral analysis decreased with aging, while results of blood pressure based tests did not. Parasympathetic activity predominated in younger subjects, while in older subjects sympathetic activity was dominant. Valsalva, deep breathing, and orthostatic ratios correlated with integrals of amplitude spectra in the standing posture and deep breathing and cold face stimulus ratios with integrals of amplitude spectra in the supine posture, whereas blood pressure changes during handgrip and orthostatic test did not correlate with integrals of the amplitude spectra. These findings suggest that tests based on heart rate may be more sensitive than tests based on blood pressure changes. This study supports the use of spectral analysis as an additional clinical test of autonomic nervous system function and stresses the importance of age in the evaluation of the results of autonomic nervous system function testing.
对83名年龄在21至70岁之间的健康男女志愿者进行了心血管反射测试结果和心率变异性频谱分析，以确定这些结果是否与年龄有关，以及两者之间是否存在相关性。心血管反射测试包括瓦尔萨尔瓦动作、深呼吸测试、握力测试、冷脸刺激测试和直立位测试，同时进行心率变异性频谱分析。我们发现，所有基于心率的测试结果和频谱分析结果均随年龄增长而下降，而基于血压的测试结果则不然。年轻受试者以副交感神经活动为主，而老年受试者则以交感神经活动为主。瓦尔萨尔瓦动作、深呼吸和直立位比值与站立位和深呼吸时的振幅谱积分相关，冷脸刺激比值与仰卧位时的振幅谱积分相关，而握力和直立位测试期间的血压变化与振幅谱积分无关。这些发现表明，基于心率的测试可能比基于血压变化的测试更敏感。本研究支持将频谱分析用作自主神经系统功能的一项附加临床测试，并强调了年龄在评估自主神经系统功能测试结果中的重要性。
