Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato-ku, Tokyo, 108-8477, Japan.
Department of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
J Antibiot (Tokyo). 2023 Nov;76(11):650-657. doi: 10.1038/s41429-023-00648-5. Epub 2023 Sep 19.
A new antibiotic named haneummycin (1) was isolated from a culture broth of marine-derived Streptomyces sp. KM77-8 by solvent extraction and HPLC using a C4 column. The structure of 1 was elucidated including relative stereochemistry as a new 22-membered macrolide lactam associated with a cyclopentanone and three sugars by various spectroscopic analyses, such as MS and NMR. Compound 1 displayed significant antibacterial activities against Gram-positive bacteria including vancomycin-resistant Enterococcus faecium (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) with both MIC values of 8.0 µg ml.
一种新型抗生素 haneummycin（1）通过溶剂萃取和 C4 柱 HPLC 从海洋来源的链霉菌 sp. KM77-8 的发酵液中分离得到。通过各种光谱分析，如 MS 和 NMR，阐明了 1 的结构，包括相对立体化学，这是一种与环戊酮和三种糖相关的新型 22 元大环内酯内酯。化合物 1 对革兰氏阳性菌具有显著的抗菌活性，包括万古霉素耐药粪肠球菌（VRE）和耐甲氧西林金黄色葡萄球菌（MRSA），其 MIC 值均为 8.0μg/ml。
