Department of Geriatrics, Tianjin Medical University General Hospital, Anshan Road No. 154, Tianjin 300052, China; Key Laboratory of Post-Trauma Neuro-Repair and Regeneration in Central Nervous System, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin Neurological Institute, Ministry of Education, Tianjin 300052, China.
Key Laboratory of Post-Trauma Neuro-Repair and Regeneration in Central Nervous System, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin Neurological Institute, Ministry of Education, Tianjin 300052, China; School of Medicine, Nankai University, Tianjin 300192, China.
Int Immunopharmacol. 2024 Sep 30;139:112712. doi: 10.1016/j.intimp.2024.112712. Epub 2024 Jul 19.
Ischemic stroke (IS) is a debilitating neurological disorder with limited treatment options. Extracellular vesicles (EVs) have emerged as crucial lipid bilayer particles derived from various cell types that facilitate intercellular communication and enable the exchange of proteins, lipids, and genetic material. Microglia are resident brain cells that play a crucial role in brain development, maintenance of neuronal networks, and injury repair. They secrete numerous extracellular vesicles in different states. Recent evidence indicates that microglia-derived extracellular vesicles (M-EVs) actively participate in mediating various biological processes, such as neuroprotection and neurorepair, in stroke, making them an excellent therapeutic approach for treating this condition. This review comprehensively summarizes the latest research on M-EVs in stroke and explores their potential as novel therapeutic targets for this disorder. Additionally, it provides an overview of the effects and functions of M-EVs on stroke recovery to facilitate the development of clinically relevant therapies for IS.
缺血性脑卒中（IS）是一种具有致残性的神经紊乱疾病，其治疗选择有限。细胞外囊泡（EVs）是源自多种细胞的重要双层脂质颗粒，它们促进细胞间通讯，并实现蛋白质、脂质和遗传物质的交换。小胶质细胞是驻留于脑内的细胞，它们在脑发育、神经元网络维持和损伤修复中发挥关键作用。它们以不同的状态分泌大量的细胞外囊泡。最近的证据表明，小胶质细胞来源的细胞外囊泡（M-EVs）积极参与调节中风中的各种生物学过程，如神经保护和神经修复，使它们成为治疗这种疾病的绝佳治疗方法。本综述全面总结了 M-EVs 在中风中的最新研究，并探讨了它们作为该疾病新型治疗靶点的潜力。此外，它还概述了 M-EVs 对中风恢复的影响和功能，以促进具有临床相关性的 IS 治疗方法的发展。
