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工程细胞外囊泡作为治疗应用中的递药系统。

Engineering Extracellular Vesicles as Delivery Systems in Therapeutic Applications.

机构信息

Department of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou City, Zhejiang Province, 310009, P. R. China.

Orthopedics Research Institute of Zhejiang University, Hangzhou City, Zhejiang Province, 310009, P. R. China.

出版信息

Adv Sci (Weinh). 2023 Jun;10(17):e2300552. doi: 10.1002/advs.202300552. Epub 2023 Apr 20.

DOI:10.1002/advs.202300552
PMID:37080941
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10265081/
Abstract

Extracellular vesicles (EVs) are transport vesicles secreted by living cells and released into the extracellular environment. Recent studies have shown that EVs serve as "messengers" in intercellular and inter-organismal communication, in both normal and pathological processes. EVs, as natural nanocarriers, can deliver bioactivators in therapy with their endogenous transport properties. This review article describes the engineering EVs of sources, isolation method, cargo loading, boosting approach, and adjustable targeting of EVs. Furthermore, the review summarizes the recent progress made in EV-based delivery systems applications, including cancer, cardiovascular diseases, liver, kidney, nervous system diseases, and COVID-19 and emphasizes the obstacles and challenges of EV-based therapies and possible strategies.

摘要

细胞外囊泡 (EVs) 是由活细胞分泌并释放到细胞外环境中的运输囊泡。最近的研究表明，EVs 在正常和病理过程中充当细胞间和生物间通讯的“信使”。EVs 作为天然的纳米载体，可通过其内在的转运特性，将生物活性剂递送至治疗部位。本文综述了 EVs 的来源、分离方法、货物装载、增强方法和 EVs 的可调节靶向等方面的工程改造。此外，本文还总结了基于 EV 的递药系统在癌症、心血管疾病、肝脏、肾脏、神经系统疾病和 COVID-19 等方面的应用的最新进展，并强调了基于 EV 的治疗方法的障碍和挑战，以及可能的策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e5f/10265081/5b42ed0375e2/ADVS-10-2300552-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e5f/10265081/751e3e2689b2/ADVS-10-2300552-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e5f/10265081/d67716cb4b42/ADVS-10-2300552-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e5f/10265081/696e3e2c629b/ADVS-10-2300552-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e5f/10265081/3d4ee0d3b561/ADVS-10-2300552-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e5f/10265081/3e9abae6e782/ADVS-10-2300552-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e5f/10265081/d20b45fe4fbb/ADVS-10-2300552-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e5f/10265081/c2695cf211cf/ADVS-10-2300552-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e5f/10265081/5b42ed0375e2/ADVS-10-2300552-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e5f/10265081/751e3e2689b2/ADVS-10-2300552-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e5f/10265081/d67716cb4b42/ADVS-10-2300552-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e5f/10265081/696e3e2c629b/ADVS-10-2300552-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e5f/10265081/3d4ee0d3b561/ADVS-10-2300552-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e5f/10265081/3e9abae6e782/ADVS-10-2300552-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e5f/10265081/d20b45fe4fbb/ADVS-10-2300552-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e5f/10265081/c2695cf211cf/ADVS-10-2300552-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e5f/10265081/5b42ed0375e2/ADVS-10-2300552-g011.jpg

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