Department of Pediatrics, University of Pittsburgh College of Medicine, Pittsburgh, Pennsylvania, USA.
Division of Endocrinology and Diabetes, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Obesity (Silver Spring). 2023 Nov;31(11):2740-2749. doi: 10.1002/oby.23887. Epub 2023 Sep 20.
The objective of this study was to quantify the effects of a 4-week, supervised, high-intensity interval training (HIIT) on intrahepatic triglyceride content (IHTG, percentage), cardiorespiratory fitness (CRF), and cardiometabolic markers in adolescents with obesity.
A total of 40 adolescents (age 13-18 y, BMI 36.7 ± 5.8 kg/m ) at risk for metabolic dysfunction-associated steatotic liver disease (MASLD) based on obesity and elevated Fibroscan measured controlled attenuation parameter (CAP) scores were randomized to HIIT three times a week for 4 weeks (n = 34) or observation (control; n = 6). Liver magnetic resonance imaging proton-density fat-fraction (MRI-PDFF), CAP, oral glucose tolerance test, serum alanine aminotransferase, dual-energy x-ray absorptiometry, and CRF tests were performed before and after intervention. Within- and between-group differences were compared.
A total of 13 (38%) and 4 (66%) children had MASLD by MRI-PDFF (IHTG ≥ 5%) in the HIIT and control groups, respectively. The implemented HIIT protocol had no impact on CRF or IHTG (baseline 5.26%, Δ = -0.31 percentage points, 95% CI: -0.77 to 0.15; p = 0.179), but it decreased the 2-h glucose concentration (baseline 116 mg/dL, Δ = -11 mg/dL; 95% CI: -17.6 to -5.5; p < 0.001). When limiting the analysis to participants with MASLD (n = 17), HIIT decreased IHTG (baseline 8.81%, Δ = -1.05 percentage points, 95% CI: -2.08 to -0.01; p = 0.048). Between-group comparisons were not different.
The implemented exercise protocol did not reduce IHTG, but it led to modest improvement in markers of cardiometabolic health.
本研究旨在量化为期 4 周、监督下的高强度间歇训练（HIIT）对肥胖青少年肝内甘油三酯含量（IHTG，百分比）、心肺功能（CRF）和心血管代谢标志物的影响。
共有 40 名青少年（年龄 13-18 岁，BMI 36.7±5.8kg/m²）因肥胖和升高的 Fibroscan 测量受控衰减参数（CAP）评分而存在代谢功能障碍相关脂肪性肝病（MASLD）风险，他们被随机分为 HIIT 组（每周 3 次，共 4 周，n=34）或观察组（对照组；n=6）。在干预前后进行了肝脏磁共振成像质子密度脂肪分数（MRI-PDFF）、CAP、口服葡萄糖耐量试验、血清丙氨酸氨基转移酶、双能 X 线吸收法和 CRF 检查。比较了组内和组间的差异。
HIIT 组和对照组分别有 13 名（38%）和 4 名（66%）儿童通过 MRI-PDFF（IHTG≥5%）诊断为 MASLD。实施的 HIIT 方案对 CRF 或 IHTG 没有影响（基线 5.26%，Δ=-0.31 个百分点，95%CI：-0.77 至 0.15；p=0.179），但它降低了 2 小时血糖浓度（基线 116mg/dL，Δ=-11mg/dL；95%CI：-17.6 至-5.5；p<0.001）。当将分析限制在 MASLD 参与者（n=17）时，HIIT 降低了 IHTG（基线 8.81%，Δ=-1.05 个百分点，95%CI：-2.08 至-0.01；p=0.048）。组间比较无差异。
实施的运动方案并未降低 IHTG，但它导致心血管代谢健康标志物的适度改善。
