Neuropsychology and Rehabilitation Psychology, Radboud University Donders Institute for Brain Cognition and Behaviour, Nijmegen, The Netherlands
Research and Innovation, Klimmendaal, Arnhem, The Netherlands.
BMJ Open. 2023 Sep 21;13(9):e067108. doi: 10.1136/bmjopen-2022-067108.
Many individuals with acquired brain injury tend to experience problems with slowed information processing speed (IPS). A potentially beneficial and cost-effective supplement for cognitive rehabilitation of impaired IPS may be the implementation of serious gaming that focuses on compensatory learning as part of cognitive training. However, most digital platforms used during cognitive rehabilitation focus on restoring cognitive function and evidence for skill transfer from digital practice to everyday life is lacking. This study aims to investigate the efficacy of a game-supported cognitive strategy training. The training combines a well-validated time pressure management cognitive strategy training, targeting slowed IPS, with a novel game and a mobile application. The game-supported training focuses on the generalisation of strategy-use to untrained tasks in everyday life.
The study is designed as a randomised controlled trial in which the experimental group (Karman Line - Tempo module: an 8-week game-supported cognitive strategy training) will be compared with an active control group (CogniPlus training: an 8-week computerised cognitive function training). Data from 60 individuals with acquired brain injury (30 per group, ages between 16 and 75) will be collected at baseline (T0), post-treatment (T1) and at 3-month follow-up (T2). The primary outcome measure is an objective assessment of compensatory strategy use in an untrained experimental task. The secondary outcome is the attainment of trained and untrained treatment goals assessed by goal attainment scaling. Pre-training and post-training data will be analysed using a 2×2 repeated measure analysis of variance.
This study has been approved by the medical review ethics committee CMO Region Arnhem and Nijmegen (NL74818.091.20) and is registered in the Netherlands Trial Register. Research findings will be published in peer-reviewed journals and presented at conferences.
NL9437; The Netherlands Trial Register.
许多后天性脑损伤患者往往存在信息处理速度（IPS）缓慢的问题。对于受损 IPS 的认知康复，一种潜在有益且具有成本效益的补充方法可能是实施专注于补偿性学习的严肃游戏，作为认知训练的一部分。然而，认知康复中使用的大多数数字平台都专注于恢复认知功能，缺乏从数字实践到日常生活中技能转移的证据。本研究旨在调查一种游戏支持的认知策略训练的效果。该训练将一种经过充分验证的时间压力管理认知策略训练（针对 IPS 缓慢）与一种新的游戏和移动应用程序相结合。游戏支持的训练侧重于将策略应用于日常生活中的未训练任务的泛化。
该研究设计为一项随机对照试验，实验组（Karman Line - Tempo 模块：为期 8 周的游戏支持认知策略训练）将与对照组（CogniPlus 训练：为期 8 周的计算机化认知功能训练）进行比较。将收集 60 名后天性脑损伤患者的数据（每组 30 人，年龄在 16 岁至 75 岁之间），基线（T0）、治疗后（T1）和 3 个月随访（T2）。主要结局指标是在未训练的实验任务中对补偿策略使用的客观评估。次要结局是通过目标实现量表评估的训练和未训练的治疗目标的实现。使用 2×2 重复测量方差分析分析预训练和后训练数据。
本研究已获得 Arnhem 和奈梅亨医学审查伦理委员会 CMO 区域（NL74818.091.20）的批准，并在荷兰试验注册处注册。研究结果将发表在同行评议的期刊上，并在会议上展示。
NL9437；荷兰试验注册处。
