Builes-Montaño C, Wandurraga E, Ramírez A, Ordóñez J E
University of Antioquia Faculty of Medicine, Medellin, Colombia.
Hospital Pablo Tobón Uribe, Medellín, Antioquia, Colombia.
Diabetes Ther. 2023 Nov;14(11):1959-1976. doi: 10.1007/s13300-023-01471-9. Epub 2023 Sep 22.
This study developed a simple algorithm based on clinical results described in medical literature and which allows one to simplify complex insulin regimes with IdegLira to avoid adverse events related to the complexity of some insulin treatments.
We conducted a systematic review of the literature that allowed us to identify studies that evaluated the clinical result of simplifying complex insulin regimes. The authors reviewed the common factors these simpler regimes had, including the type of patients who used them.
We found nine clinical studies published between 2017 and 2022, eight performed in Europe and one in Latin America. The monitoring time of the studies ranged between 3 and 18 months. The size of the study populations was between 61 and 611 patients (the latter was in five countries). In all studies, HbA1c decreased by 0.6-1.7% and the weight decreased by 0.1-3.11 kg.
On the basis of the findings of these studies, we made some recommendations for clinical practice to simplify treatment. The results of these studies support an algorithm that simplifies the treatment of complex insulin regimens.
本研究基于医学文献中描述的临床结果开发了一种简单算法，该算法可简化使用德谷胰岛素利拉鲁肽的复杂胰岛素治疗方案，以避免因某些胰岛素治疗方案复杂而导致的不良事件。
我们对文献进行了系统综述，以确定评估简化复杂胰岛素治疗方案临床结果的研究。作者回顾了这些更简单治疗方案的共同因素，包括使用这些方案的患者类型。
我们发现了2017年至2022年间发表的9项临床研究，其中8项在欧洲进行，1项在拉丁美洲进行。研究的监测时间为3至18个月。研究人群规模在61至611名患者之间（后者涉及五个国家）。在所有研究中，糖化血红蛋白（HbA1c）下降了0.6 - 1.7%，体重下降了0.1 - 3.11千克。
基于这些研究结果，我们为临床实践提出了一些简化治疗的建议。这些研究结果支持一种简化复杂胰岛素治疗方案的算法。
