Xu Qian, Cheng Wen, Wei Jinrui, Ou Yan, Xiao Xian, Jia Yingjie
Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China.
Discov Oncol. 2023 Sep 24;14(1):179. doi: 10.1007/s12672-023-00798-w.
Various new treatments are emerging constantly in anti-tumor therapies, including chemotherapy, immunotherapy, and targeted therapy. However, the efficacy is still not satisfactory. Astragalus polysaccharide is an important bioactive component derived from the dry root of Radix astragali. Studies found that astragalus polysaccharides have gained great significance in increasing the sensitivity of anti-tumor treatment, reducing the side effects of anti-tumor treatment, reversing the drug resistance of anti-tumor drugs, etc. In this review, we focused on the role of astragalus polysaccharides in tumor immune microenvironment. We reviewed the immunomodulatory effect of astragalus polysaccharides on macrophages, dendritic cells, natural killer cells, T lymphocytes, and B lymphocytes. We found that astragalus polysaccharides can promote the activities of macrophages, dendritic cells, natural killer cells, T lymphocytes, and B lymphocytes and induce the expression of a variety of cytokines and chemokines. Furthermore, we summarized the clinical applications of astragalus polysaccharides in patients with digestive tract tumors. We summarized the effective mechanism of astragalus polysaccharides on digestive tract tumors, including apoptosis induction, proliferation inhibition, immunoactivity regulation, enhancement of the anticancer effect and chemosensitivity. Therefore, in view of the multiple functions of astragalus polysaccharides in tumor immune microenvironment and its clinical efficacy, the combination of astragalus polysaccharides with antitumor therapy such as immunotherapy may provide new sparks to the bottleneck of current treatment methods.
在抗肿瘤治疗中，各种新的治疗方法不断涌现，包括化疗、免疫治疗和靶向治疗。然而，其疗效仍不尽人意。黄芪多糖是从黄芪干燥根中提取的一种重要生物活性成分。研究发现，黄芪多糖在提高抗肿瘤治疗敏感性、降低抗肿瘤治疗副作用、逆转抗肿瘤药物耐药性等方面具有重要意义。在本综述中，我们重点关注了黄芪多糖在肿瘤免疫微环境中的作用。我们综述了黄芪多糖对巨噬细胞、树突状细胞、自然杀伤细胞、T淋巴细胞和B淋巴细胞的免疫调节作用。我们发现黄芪多糖可以促进巨噬细胞、树突状细胞、自然杀伤细胞、T淋巴细胞和B淋巴细胞的活性，并诱导多种细胞因子和趋化因子的表达。此外，我们总结了黄芪多糖在消化道肿瘤患者中的临床应用。我们总结了黄芪多糖对消化道肿瘤的有效作用机制，包括诱导凋亡、抑制增殖、调节免疫活性、增强抗癌效果和化疗敏感性。因此，鉴于黄芪多糖在肿瘤免疫微环境中的多种功能及其临床疗效，黄芪多糖与免疫治疗等抗肿瘤治疗方法的联合应用可能为当前治疗方法的瓶颈带来新的突破。
