Andriulli A, Arrigoni A, Gindro T, Verme G
Minerva Med. 1986 Oct 13;77(39):1801-5.
Aim of this study was to re-evaluate the overall prevalence of a peptic disease in 350 patients with liver diseases of different etiology and severity. A normal endoscopic picture was found in 82% of cases. Peptic lesions were found in 18% of total cases and were located in the duodenal (10.9%) and gastric (7.1%) wall. On the basis of the 15-20% rate, which most Authors think to be a reasonable estimate of the overall ulcer prevalence in normal population, the prevalence rate in this survey would suggest that there is no association between ulcer and liver disease. Ulcers were more commonly present in cirrhotic than in noncirrhotic patients. Both alcohol intake and cigarette smoking were identified as two ulcerogenic events in these patients while portal hypertension and etiology of liver disease were irrelevant factors. The contemporary occurrence of the three ulcerogenic factors (cirrhosis, smoking, and alcohol intake) in a given patient seems to potentiate each others as ulcerogenic event. It is concluded that patients with liver diseases share the same risk of developing a peptic disease as the general population.
本研究的目的是重新评估350例不同病因和严重程度的肝病患者中消化性疾病的总体患病率。82%的病例内镜检查结果正常。在所有病例中，18%发现有消化性病变，位于十二指肠壁（10.9%）和胃壁（7.1%）。根据大多数作者认为的正常人群溃疡总体患病率的合理估计值15%-20%，本次调查的患病率表明溃疡与肝病之间没有关联。溃疡在肝硬化患者中比在非肝硬化患者中更常见。饮酒和吸烟被确定为这些患者发生溃疡的两个诱发因素，而门静脉高压和肝病病因则是无关因素。在特定患者中，三种致溃疡因素（肝硬化、吸烟和饮酒）同时出现似乎会相互增强致溃疡作用。得出的结论是，肝病患者患消化性疾病的风险与普通人群相同。
