• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基于ZIF-8的材料在生物医学领域的合成方法、结构及近期趋势

Synthesis methods, structure, and recent trends of ZIF-8-based materials in the biomedical field.

作者信息

Tran Thuan Van, Dang Hoang Huy, Nguyen Huy, Nguyen Ngoan Thi Thao, Nguyen Dai Hai, Nguyen Thuy Thi Thanh

机构信息

Institute of Applied Technology and Sustainable Development, Nguyen Tat Thanh University 298-300A Nguyen Tat Thanh, District 4 Ho Chi Minh City 755414 Vietnam

Nong Lam University Ho Chi Minh City Ho Chi Minh City 700000 Vietnam

出版信息

Nanoscale Adv. 2025 May 27. doi: 10.1039/d4na01015a.

DOI:10.1039/d4na01015a
PMID:40438665
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12109618/
Abstract

Zeolitic imidazolate framework-8 (ZIF-8) is a highly porous material with remarkable structural properties and high drug-loading capacity, and hence this material presents as an exceptional candidate for advanced drug delivery systems. Herein, we comprehensively review the recent developments in ZIF-8 synthesis techniques and critically discuss innovative approaches such as the use of green solvents and advanced methods such as microwave- and ultrasound-assisted syntheses. The multifunctional applications of ZIF-8-based biomaterials in biomedical engineering are critically explored with their pivotal roles in antibacterial and anticancer therapies, drug delivery systems, bone tissue engineering, and diagnostic platforms such as biosensing and bioimaging. The present review also clarifies some innovations of ZIF-8-based materials in pH-sensitive and glucose-responsive drug delivery systems and scaffolds for bone regeneration. Despite these promising advancements, we analyze critical concerns, such as the release of Zn(ii) ions, potential cytotoxicity, and biocompatibility challenges, which remain significant hurdles to the broader adoption of ZIF-8. Addressing these outlined challenges may be necessary in realizing the potential of ZIF-8 in biomedical applications.

摘要

沸石咪唑酯骨架材料-8（ZIF-8）是一种具有卓越结构特性和高载药能力的高度多孔材料，因此该材料是先进药物递送系统的极佳候选者。在此，我们全面综述了ZIF-8合成技术的最新进展，并批判性地讨论了诸如使用绿色溶剂等创新方法以及诸如微波和超声辅助合成等先进方法。基于ZIF-8的生物材料在生物医学工程中的多功能应用得到了批判性探索，它们在抗菌和抗癌治疗、药物递送系统、骨组织工程以及诸如生物传感和生物成像等诊断平台中发挥着关键作用。本综述还阐明了基于ZIF-8的材料在pH敏感和葡萄糖响应性药物递送系统以及骨再生支架方面的一些创新。尽管取得了这些有前景的进展，但我们分析了一些关键问题，例如Zn(ii)离子的释放、潜在的细胞毒性以及生物相容性挑战，这些仍然是ZIF-8更广泛应用的重大障碍。解决这些概述的挑战对于实现ZIF-8在生物医学应用中的潜力可能是必要的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f3c/12186653/b0a1a3db6e58/d4na01015a-f13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f3c/12186653/8f13ac94a1e0/d4na01015a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f3c/12186653/14ba426d03a2/d4na01015a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f3c/12186653/e90c0af8ac15/d4na01015a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f3c/12186653/607243f0c585/d4na01015a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f3c/12186653/747f41e963b4/d4na01015a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f3c/12186653/8c55ad5d627a/d4na01015a-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f3c/12186653/46c1405c6bb0/d4na01015a-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f3c/12186653/fb0d13cf68dd/d4na01015a-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f3c/12186653/56c5fdcdbedd/d4na01015a-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f3c/12186653/5dbe102102dd/d4na01015a-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f3c/12186653/608d202ea3e1/d4na01015a-f11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f3c/12186653/8462d5e46929/d4na01015a-f12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f3c/12186653/b0a1a3db6e58/d4na01015a-f13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f3c/12186653/8f13ac94a1e0/d4na01015a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f3c/12186653/14ba426d03a2/d4na01015a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f3c/12186653/e90c0af8ac15/d4na01015a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f3c/12186653/607243f0c585/d4na01015a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f3c/12186653/747f41e963b4/d4na01015a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f3c/12186653/8c55ad5d627a/d4na01015a-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f3c/12186653/46c1405c6bb0/d4na01015a-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f3c/12186653/fb0d13cf68dd/d4na01015a-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f3c/12186653/56c5fdcdbedd/d4na01015a-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f3c/12186653/5dbe102102dd/d4na01015a-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f3c/12186653/608d202ea3e1/d4na01015a-f11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f3c/12186653/8462d5e46929/d4na01015a-f12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f3c/12186653/b0a1a3db6e58/d4na01015a-f13.jpg

相似文献

1
Synthesis methods, structure, and recent trends of ZIF-8-based materials in the biomedical field.基于ZIF-8的材料在生物医学领域的合成方法、结构及近期趋势
Nanoscale Adv. 2025 May 27. doi: 10.1039/d4na01015a.
2
Recent progress in ZIF-polymer composites for advanced drug delivery applications.用于先进药物递送应用的ZIF-聚合物复合材料的最新进展。
J Mater Chem B. 2025 Jun 18;13(24):6949-6989. doi: 10.1039/d5tb00147a.
3
Study on the Application of Zeolitic Imidazolate Framework-8 Loaded With Artemisia Argyi Essential Oil in the Treatment of Bacterial Infected Wounds.载艾草精油的沸石咪唑酯骨架材料-8在治疗细菌感染伤口中的应用研究
J Biomed Mater Res A. 2025 Jun;113(6):e37937. doi: 10.1002/jbm.a.37937.
4
Emergence of snail mucus as a multifunctional biogenic material for biomedical applications.蜗牛黏液作为一种用于生物医学应用的多功能生物材料的出现。
Acta Biomater. 2025 May 2. doi: 10.1016/j.actbio.2025.05.006.
5
3D printed metamaterials: properties, fabrication, and drug delivery applications.3D打印超材料：特性、制造及药物递送应用
Adv Drug Deliv Rev. 2025 Jun 9;224:115636. doi: 10.1016/j.addr.2025.115636.
6
Rapid molecular tests for tuberculosis and tuberculosis drug resistance: a qualitative evidence synthesis of recipient and provider views.快速分子检测结核分枝杆菌和结核分枝杆菌耐药性：受检者和提供者观点的定性证据综合评价。
Cochrane Database Syst Rev. 2022 Apr 26;4(4):CD014877. doi: 10.1002/14651858.CD014877.pub2.
7
Systemic treatments for metastatic cutaneous melanoma.转移性皮肤黑色素瘤的全身治疗
Cochrane Database Syst Rev. 2018 Feb 6;2(2):CD011123. doi: 10.1002/14651858.CD011123.pub2.
8
Community views on mass drug administration for soil-transmitted helminths: a qualitative evidence synthesis.社区对土壤传播蠕虫群体药物给药的看法：定性证据综合分析
Cochrane Database Syst Rev. 2025 Jun 20;6:CD015794. doi: 10.1002/14651858.CD015794.pub2.
9
The use of Open Dialogue in Trauma Informed Care services for mental health consumers and their family networks: A scoping review.创伤知情护理服务中使用开放对话模式为心理健康消费者及其家庭网络提供服务：范围综述。
J Psychiatr Ment Health Nurs. 2024 Aug;31(4):681-698. doi: 10.1111/jpm.13023. Epub 2024 Jan 17.
10
Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID-19.在基层医疗机构或医院门诊环境中，如果患者出现以下症状和体征，可判断其是否患有 COVID-19。
Cochrane Database Syst Rev. 2022 May 20;5(5):CD013665. doi: 10.1002/14651858.CD013665.pub3.

本文引用的文献

1
Unified Roadmap for ZIF-8 Nucleation and Growth: Machine Learning Analysis of Synthetic Variables and Their Impact on Particle Size and Morphology.ZIF-8成核与生长的统一路线图：合成变量的机器学习分析及其对粒径和形态的影响
Chem Mater. 2024 May 20;36(11):5814-5825. doi: 10.1021/acs.chemmater.4c01069. eCollection 2024 Jun 11.
2
Surfactant-Free, Size-Controllable, and Scalable Green Synthesis of ZIF-8 Particles with Narrow Size Distribution by Tuning Key Reaction Parameters in Water Solvent.通过调节水溶剂中的关键反应参数，无表面活性剂、尺寸可控且可扩展地绿色合成窄尺寸分布的ZIF-8颗粒
Small Methods. 2024 Dec;8(12):e2400236. doi: 10.1002/smtd.202400236. Epub 2024 May 2.
3
A review on MOFs synthesis and effect of their structural characteristics for hydrogen adsorption.
金属有机框架材料（MOFs）的合成及其结构特征对氢气吸附影响的综述。
RSC Adv. 2024 Apr 30;14(20):14233-14253. doi: 10.1039/d4ra00865k. eCollection 2024 Apr 25.
4
Reproductive and whole-body toxicity of Ag-doped and -undoped ZIF-8 nanoparticles and the building blocks: An Artemia-based comparative bioassay.载银和未载银 ZIF-8 纳米粒子及其构筑块对生殖和全身的毒性：基于卤虫的比较生物测定。
Environ Pollut. 2024 Feb 1;342:123141. doi: 10.1016/j.envpol.2023.123141. Epub 2023 Dec 12.
5
Structural Chemistry of Zeolitic Imidazolate Frameworks.沸石咪唑酯骨架结构化学
Inorg Chem. 2023 Dec 25;62(51):20861-20873. doi: 10.1021/acs.inorgchem.3c02322. Epub 2023 Dec 8.
6
Zeolite imidazolate framework-8 in bone regeneration: A systematic review.沸石咪唑酯骨架-8 在骨再生中的应用：系统评价。
J Control Release. 2024 Jan;365:558-582. doi: 10.1016/j.jconrel.2023.11.049. Epub 2023 Dec 6.
7
Functionalization strategies of metal-organic frameworks for biomedical applications and treatment of emerging pollutants: A review.用于生物医学应用和新兴污染物处理的金属有机骨架的功能化策略：综述。
Sci Total Environ. 2024 Jan 1;906:167295. doi: 10.1016/j.scitotenv.2023.167295. Epub 2023 Sep 22.
8
Zeolitic imidazolate frameworks: From bactericidal properties to tissue regeneration.沸石咪唑酯骨架材料：从杀菌性能到组织再生。
J Control Release. 2023 Jul;359:326-346. doi: 10.1016/j.jconrel.2023.06.002. Epub 2023 Jun 14.
9
Breakdown of biomass for energy applications using microwave pyrolysis: A technological review.微波热解生物质用于能源应用的研究进展综述。
Environ Res. 2023 Jun 1;226:115619. doi: 10.1016/j.envres.2023.115619. Epub 2023 Mar 9.
10
Understanding the ZIF-L to ZIF-8 transformation from fundamentals to fully costed kilogram-scale production.了解从基础原理到完全成本核算的千克级生产的ZIF-L到ZIF-8的转变。
Commun Chem. 2022 Feb 9;5(1):18. doi: 10.1038/s42004-021-00613-z.