Jameson J Brian, Wang Jiaming, Bailey Patrick C, Oldham Michael J, Smith Cameron R, Jeong Lena N, Cook David K, Bates Austin L, Ullah Sifat, Pennington Alexander S C, Gillman I Gene
Juul Labs, Inc., Washington, DC, United States.
Front Chem. 2023 Sep 7;11:1223967. doi: 10.3389/fchem.2023.1223967. eCollection 2023.
Literature reports the chemical constituent yields of electronic nicotine delivery systems (ENDS) aerosol collected using a range of aerosol collection strategies. The number of puffs to deplete an ENDS product varies widely, but collections often consist of data from the first 50-100 puffs. However, it is not clear whether these discrete puff blocks are representative of constituent yields over the life of a pod. We aimed to assess the effect of differing aerosol collection strategies on reported yields for select chemical constituents in the aerosol of closed pod-based ENDS products. Constituents analyzed were chosen to reflect important classes of compounds from the Final Premarket Tobacco Product Application Guidance. Yields were normalized to total device mass loss (DML). Collection strategies that consisted of partial pod collection were valid for determining yields of constituents whose DML normalized yields were consistent for the duration of pod life. These included primary aerosol constituents, such as propylene glycol, glycerol, and nicotine, and whole pod yields could be determined from initial puff blocks. However, changes were observed in the yields of some metals, some carbonyl compounds, and glycidol over pod life in a chemical constituent and product dependent manner. These results suggest that collection strategies consisting of initial puff block collections require validation per chemical constituent/product and are not appropriate for chemical constituents with variable yields over pod life. Whole pod collection increased sensitivity and accuracy in determining metal, carbonyl, and glycidol yields compared to puff block-based collection methodologies for all products tested.
文献报道了使用一系列气溶胶收集策略收集的电子尼古丁传送系统（ENDS）气溶胶的化学成分产量。耗尽一个ENDS产品所需的抽吸次数差异很大，但收集的数据通常来自前50 - 100次抽吸。然而，尚不清楚这些离散的抽吸组是否代表了一个烟弹使用寿命期间的成分产量。我们旨在评估不同的气溶胶收集策略对基于封闭式烟弹的ENDS产品气溶胶中选定化学成分报告产量的影响。所分析的成分是从最终上市前烟草产品应用指南中挑选出来的，以反映重要的化合物类别。产量被归一化为总装置质量损失（DML）。由部分烟弹收集组成的收集策略对于确定那些DML归一化产量在烟弹使用寿命期间保持一致的成分的产量是有效的。这些成分包括主要气溶胶成分，如丙二醇、甘油和尼古丁，并且可以从初始抽吸组确定整个烟弹的产量。然而，在烟弹使用寿命期间，一些金属、一些羰基化合物和缩水甘油的产量以化学成分和产品依赖的方式发生了变化。这些结果表明，由初始抽吸组收集组成的收集策略需要针对每个化学成分/产品进行验证，并且不适用于在烟弹使用寿命期间产量可变的化学成分。与基于抽吸组的收集方法相比，对于所有测试产品，整个烟弹收集在确定金属、羰基和缩水甘油产量方面提高了灵敏度和准确性。
