Organometallics and Nanomaterials, Department of Chemical Sciences, University of the Western Cape, Bellville 7535, South Africa.
Department of Science and Innovation (DSI)/Mintek Nanotechnology Innovation Centre (NIC)-Biolabels Node, Department of Biotechnology, University of the Western Cape, Bellville 7535, South Africa.
Int J Mol Sci. 2021 Oct 19;22(20):11272. doi: 10.3390/ijms222011272.
Since antiquity, silver-based therapies have been used in wound healing, wound care and management of infections to provide adequate healing. These therapies are associated with certain limitations, such as toxicity, skin discolouration and bacterial resistance, which have limited their use. As a result, new and innovative wound therapies, or strategies to improve the existing therapies, are sought after. Silver nanoparticles (AgNPs) have shown the potential to circumvent the limitations associated with conventional silver-based therapies as described above. AgNPs are effective against a broad spectrum of microorganisms and are less toxic, effective at lower concentrations and produce no skin discolouration. Furthermore, AgNPs can be decorated or coupled with other healing-promoting materials to provide optimum healing. This review details the history and impact of silver-based therapies leading up to AgNPs and AgNP-based nanoformulations in wound healing. It also highlights the properties of AgNPs that aid in wound healing and that make them superior to conventional silver-based wound treatment therapies.
自古以来，银基疗法就在伤口愈合、伤口护理和感染管理中得到应用，以提供充分的愈合。这些疗法存在一定的局限性，如毒性、皮肤变色和细菌耐药性，这限制了它们的使用。因此，人们正在寻求新的和创新的伤口治疗方法，或改善现有治疗方法的策略。正如上文所述，银纳米粒子（AgNPs）显示出规避与传统银基疗法相关的局限性的潜力。AgNPs 对广谱微生物有效，毒性较低，在较低浓度下有效，且不会导致皮肤变色。此外，AgNPs 可以用其他促进愈合的材料进行修饰或偶联，以提供最佳的愈合效果。本综述详细介绍了银基疗法的历史和影响，以及 AgNPs 和基于 AgNPs 的纳米制剂在伤口愈合中的应用。它还强调了 AgNPs 有助于伤口愈合的特性，使其优于传统的银基伤口治疗疗法。
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