Fang Qiaojun, Wei Yongjie, Zhang Yuhua, Cao Wei, Yan Lin, Kong Mengdie, Zhu Yongjun, Xu Yan, Guo Lingna, Zhang Lei, Wang Weiqing, Yu Yafeng, Sun Jingwu, Yang Jianming
Department of Otolaryngology-Head and Neck Surgery, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
School of Life Sciences and Technology, Southeast University, Nanjing, China.
Front Neurosci. 2023 Sep 7;17:1259889. doi: 10.3389/fnins.2023.1259889. eCollection 2023.
Hearing impairment is a global health problem. Stem cell therapy has become a cutting-edge approach to tissue regeneration. In this review, the recent advances in stem cell therapy for hearing loss have been discussed. Nanomaterials can modulate the stem cell microenvironment to augment the therapeutic effects further. The potential of combining nanomaterials with stem cells for repairing and regenerating damaged inner ear hair cells (HCs) and spiral ganglion neurons (SGNs) has also been discussed. Stem cell-derived exosomes can contribute to the repair and regeneration of damaged tissue, and the research progress on exosome-based hearing loss treatment has been summarized as well. Despite stem cell therapy's technical and practical limitations, the findings reported so far are promising and warrant further investigation for eventual clinical translation.
听力障碍是一个全球性的健康问题。干细胞疗法已成为组织再生的前沿方法。在这篇综述中，讨论了干细胞疗法治疗听力损失的最新进展。纳米材料可以调节干细胞微环境以进一步增强治疗效果。还讨论了将纳米材料与干细胞结合用于修复和再生受损内耳毛细胞（HCs）和螺旋神经节神经元（SGNs）的潜力。干细胞衍生的外泌体有助于受损组织的修复和再生，并且也总结了基于外泌体的听力损失治疗的研究进展。尽管干细胞疗法存在技术和实际限制，但迄今为止报道的研究结果很有前景，值得进一步研究以便最终实现临床转化。
