Mohamad Tamam, Jyotsna Fnu, Farooq Umer, Fatima Aroob, Kar Indrani, Khuwaja Sundal, Memon Unaib Ahmed, Kumari Versha, Puri Piyush, Aslam Zaid M, Elder Zachary, Varrassi Giustino, Paladini Antonella, Khatri Mahima, Kumar Satesh, Muzammil Muhammad Ali
Cardiology, Wayne State University, Detroit, USA.
Medicine, Dr. B.R. Ambedkar State Institute of Medical Sciences, Mohali, IND.
Cureus. 2023 Aug 23;15(8):e43977. doi: 10.7759/cureus.43977. eCollection 2023 Aug.
The field of cardiovascular medicine is undergoing a transformative shift towards personalized medicinal therapy, particularly in the context of post stent implantation. This narrative review explores the significance, challenges, and future directions of individualized treatment strategies for patients with coronary stents. The review highlights the pivotal role of personalized approaches in optimizing treatment efficacy and minimizing adverse events. Real-world clinical studies and trials underscore the importance of tailoring antiplatelet therapy based on platelet function testing, genetic testing, and risk scoring. These studies reveal that personalized medicinal treatment improves clinical outcomes by balancing preventing thrombotic events and mitigating bleeding risks. Challenges, including cost, test availability, patient adherence, and ethical considerations, are discussed in depth, shedding light on the complexities of implementing personalized approaches. Technological advancements, including omics data integration, artificial intelligence, and big data analytics, shape the future of personalized medicinal therapy. These tools enable precise pharmacogenomic selection of medications and the development of integrated risk-scoring systems. Patient engagement and education are also central, with empowered patients and remote monitoring contributing to collaborative decision-making. In conclusion, the narrative review underscores that personalized medicinal therapy post stent implantation holds immense promise for revolutionizing cardiovascular care. By embracing a comprehensive approach that considers genetics, clinical factors, and patient preferences, healthcare providers can optimize treatment outcomes and improve patient quality of life. The evolving landscape of personalized medicine offers a glimpse into a future where tailored treatment strategies become the cornerstone of precision cardiovascular care.
心血管医学领域正在经历向个性化药物治疗的变革性转变，尤其是在支架植入术后的背景下。这篇叙述性综述探讨了冠状动脉支架患者个体化治疗策略的意义、挑战和未来方向。该综述强调了个性化方法在优化治疗效果和最小化不良事件方面的关键作用。真实世界的临床研究和试验强调了基于血小板功能测试、基因检测和风险评分来调整抗血小板治疗的重要性。这些研究表明，个性化药物治疗通过平衡预防血栓形成事件和降低出血风险来改善临床结果。深入讨论了包括成本、检测可用性、患者依从性和伦理考量在内的挑战，揭示了实施个性化方法的复杂性。技术进步，包括组学数据整合、人工智能和大数据分析，塑造了个性化药物治疗的未来。这些工具能够实现药物的精确药物基因组学选择并开发综合风险评分系统。患者参与和教育也至关重要，赋权患者和远程监测有助于共同决策。总之，这篇叙述性综述强调，支架植入术后的个性化药物治疗有望彻底改变心血管护理。通过采用一种综合方法，考虑遗传学、临床因素和患者偏好，医疗保健提供者可以优化治疗结果并提高患者生活质量。个性化医学不断发展的格局让人瞥见一个未来，在这个未来，量身定制的治疗策略将成为精准心血管护理的基石。
