Ali Asmaa, Wu Liang, Ali Sameh Samir
Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, 212013, China.
Department of Pulmonary Medicine, Abbassia Chest Hospital, MOH, Cairo, Egypt.
Int Urol Nephrol. 2024 Apr;56(4):1345-1358. doi: 10.1007/s11255-023-03760-5. Epub 2023 Sep 26.
The gut microbiota, often called the "forgotten organ," plays a crucial role in bidirectional communication with the host for optimal physiological function. This communication helps regulate the host's immunity and metabolism positively and negatively. Many factors influence microbiota homeostasis and subsequently lead to an immune system imbalance. The correlation between an unbalanced immune system and acute diseases such as acute kidney injury is not fully understood, and the role of gut microbiota in disease pathogenesis is still yet uncovered. This review summarizes our understanding of gut microbiota, focusing on the interactions between the host's immune system and the microbiome and their impact on acute kidney injury.
肠道微生物群通常被称为“被遗忘的器官”，在与宿主进行双向交流以实现最佳生理功能方面发挥着关键作用。这种交流对宿主的免疫和代谢起着正负两方面的调节作用。许多因素会影响微生物群的稳态，进而导致免疫系统失衡。免疫系统失衡与急性肾损伤等急性疾病之间的关联尚未完全明确，肠道微生物群在疾病发病机制中的作用仍有待揭示。本综述总结了我们对肠道微生物群的认识，重点关注宿主免疫系统与微生物组之间的相互作用及其对急性肾损伤的影响。
