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乳糜泻中针对膳食抗原的抗体。

Antibodies to dietary antigens in coeliac disease.

作者信息

Volta U, Lazzari R, Bianchi F B, Lenzi M, Baldoni A M, Cassani F, Collina A, Pisi E

出版信息

Scand J Gastroenterol. 1986 Oct;21(8):935-40. doi: 10.3109/00365528608996398.

DOI:10.3109/00365528608996398
PMID:3775259
Abstract

Antibodies to gliadin (AGA) were found in 77 (94%) of 82 sera from patients with active coeliac disease (untreated and after gluten challenge). Although IgG AGA had a higher nosological sensitivity than IgA AGA (88% versus 67%), their nosological specificity was lower than that of IgA antibodies (87% versus 100%). The sensitivity of antibodies to casein, beta-lactoglobulin, and ovalbumin in active coeliac disease varied from 36% to 48% without significant difference between IgG and IgA antibodies. IgG and IgA antibodies to milk and egg proteins showed a specificity similar to that of AGA, although some IgA antibodies other than AGA were found in disease controls (Crohn's disease, ulcerative colitis, post-enteritis syndrome).

摘要

在82例活动性乳糜泻患者(未经治疗以及麸质激发后)的血清中,有77例(94%)检测到了抗麦醇溶蛋白抗体(AGA)。尽管IgG AGA的病因学敏感性高于IgA AGA(88%对67%),但其病因学特异性低于IgA抗体(87%对100%)。在活动性乳糜泻中,抗酪蛋白、β-乳球蛋白和卵清蛋白抗体的敏感性在36%至48%之间,IgG和IgA抗体之间无显著差异。针对牛奶和鸡蛋蛋白的IgG和IgA抗体显示出与AGA相似的特异性,不过在疾病对照(克罗恩病、溃疡性结肠炎、肠炎后综合征)中发现了一些除AGA外的IgA抗体。

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引用本文的文献

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Is Gluten the Only Culprit for Non-Celiac Gluten/Wheat Sensitivity? gluten 是引起非麸质/小麦敏感的唯一原因吗?
Nutrients. 2020 Dec 10;12(12):3785. doi: 10.3390/nu12123785.
2
Anti-gliadin antibody specificity for gluten-derived peptides toxic to coeliac patients.抗麦醇溶蛋白抗体对麸质来源的、对乳糜泻患者有毒性的肽段的特异性。
Clin Exp Immunol. 1989 Jun;76(3):384-90.
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IgG, IgA and IgE gliadin antibody determinations as screening test for untreated coeliac disease in children, a multicentre study.IgG、IgA和IgE麦醇溶蛋白抗体检测作为儿童未经治疗的乳糜泻筛查试验:一项多中心研究
Eur J Pediatr. 1989 Apr;148(6):496-502. doi: 10.1007/BF00441541.
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IgA subclass antibodies to gliadin in serum and intestinal juice of patients with coeliac disease.乳糜泻患者血清和肠液中针对麦醇溶蛋白的IgA亚类抗体。
Clin Exp Immunol. 1990 May;80(2):192-5. doi: 10.1111/j.1365-2249.1990.tb05232.x.
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IgA antiendomysial antibody test. A step forward in celiac disease screening.IgA抗肌内膜抗体检测。乳糜泻筛查的一项进展。
Dig Dis Sci. 1991 Jun;36(6):752-6. doi: 10.1007/BF01311232.