Shen Ning, Wang Lijuan, Wu Jingjing, Chen Xuefang, Hu Fengchao, Su Yi
Department of Oncology, Zhangqiu People's Hospital, Jinan, Shandong 250200, P.R. China.
Blood Purification Center, Suzhou Science and Technology Town Hospital, Suzhou, Jiangsu 215153, P.R. China.
Exp Ther Med. 2023 Sep 6;26(4):492. doi: 10.3892/etm.2023.12191. eCollection 2023 Oct.
Microtubule-associated protein 1 light chain 3 (LC3) is an autophagy-associated gene, which is involved in the progression of a number of human malignancies. Such as Breast Cancer, Liver Cancer, and Lung Cancer. However, the role of LC3 in colorectal cancer (CC) remains to be fully elucidated. Therefore, the prognostic role of LC3 expression in CC was evaluated in the present study, with an emphasis on the clinicopathology and prognosis. Expression of LC3 in CC was examined using PubMed, Cochrane Library, Excerpta Medica Database, China Knowledge Infrastructure and Wanfang Data. Newcastle-Ottawa scale was used to screen the literature quality, and RevMan 5.4 and STATA 14.0 were used for the meta-analysis. A total of 1,689 patients from 10 studies were included in the present meta-analysis. The findings of the present study suggested that increased LC3 expression levels were associated with histological grade [odds ratio (OR)=0.91, 95% confidence interval (CI) (0.47, 1.77), P<0.001] and TNM stage [OR=0.91, 95% CI (0.47, 1.77), P<0.001], but were not associated with sex [OR=1.14, 95% CI (0.90, 1.51)], age [OR=0.89, 95% CI (0.67, 1.20)], tumor size [OR=0.78, 95% CI (0.30, 2.34)], histological grade [OR=0.82, 95% CI (0.43, 1.95)] and lymph node metastasis [OR=2.05, 95% CI (1.19, 3.60)] in CC. In addition, the increased expression of LC3 was revealed to be a prognostic factor for the overall survival of patients with CC. In conclusion, the autophagy-associated protein LC3 may be a prognostic indicator of human CC.
微管相关蛋白1轻链3（LC3）是一种自噬相关基因，它参与多种人类恶性肿瘤的进展。如乳腺癌、肝癌和肺癌。然而，LC3在结直肠癌（CC）中的作用仍有待充分阐明。因此，本研究评估了LC3表达在CC中的预后作用，重点关注临床病理学和预后。通过PubMed、Cochrane图书馆、医学文摘数据库、中国知网和万方数据检索CC中LC3的表达情况。采用纽卡斯尔-渥太华量表筛选文献质量，并用RevMan 5.4和STATA 14.0进行荟萃分析。本荟萃分析共纳入来自10项研究的1689例患者。本研究结果表明，LC3表达水平升高与组织学分级[比值比（OR）=0.91，95%置信区间（CI）（0.47，1.77），P<0.001]和TNM分期[OR=0.91，95%CI（0.47，1.77），P<0.001]相关，但与CC患者的性别[OR=1.14，95%CI（0.90，1.51）]、年龄[OR=0.89，95%CI（0.67，1.20）]、肿瘤大小[OR=0.78，95%CI（0.30，2.34）]、组织学分级[OR=0.82，95%CI（0.43，1.95）]和淋巴结转移[OR=2.05，95%CI（1.19，3.60）]无关。此外，LC3表达增加被证明是CC患者总生存的一个预后因素。总之，自噬相关蛋白LC3可能是人类CC的一个预后指标。
