Benedict Kaitlin, Hennessee Ian, Gold Jeremy A W, Smith Dallas J, Williams Samantha, Toda Mitsuru
Mycotic Diseases Branch, Division of Foodborne, Waterborne and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
J Fungi (Basel). 2023 Aug 22;9(9):867. doi: 10.3390/jof9090867.
Blastomycosis is an environmentally acquired fungal disease that can cause severe illness, with approximately 65% of reported cases requiring hospitalization. Recent trends in blastomycosis-associated hospitalizations in the United States have not been described.
We analyzed hospital discharge data from the Healthcare Cost and Utilization Project (HCUP) National (Nationwide) Inpatient Sample. We calculated hospitalization rates per 100,000 population using U.S. census data and examined factors associated with in-hospital mortality.
An estimated 11,776 blastomycosis-associated hospitalizations occurred during 2010-2020 (average yearly rate 0.3 per 100,000 persons), with no apparent temporal trend. Rates were consistently highest among persons ≥65 years old and males. In-hospital death occurred in 7.9% and approximately doubled from 3.9% in 2010 to 8.5% in 2020. Older age, chronic obstructive pulmonary disease, and malignancy were associated with mortality.
Blastomycosis-associated hospitalizations can result in poor outcomes, underscoring the continued need for attention to early detection and treatment of blastomycosis and monitoring of disease trends.
芽生菌病是一种通过环境感染的真菌疾病，可导致严重疾病，约65%的报告病例需要住院治疗。美国芽生菌病相关住院治疗的近期趋势尚未得到描述。
我们分析了医疗成本和利用项目（HCUP）国家（全国）住院患者样本的医院出院数据。我们使用美国人口普查数据计算每10万人的住院率，并研究与住院死亡率相关的因素。
2010 - 2020年期间估计发生了11776例芽生菌病相关住院病例（平均年发病率为每10万人0.3例），没有明显的时间趋势。≥65岁人群和男性的发病率一直最高。住院死亡率为7.9%，从2010年的3.9%增至2020年的8.5%，几乎翻了一番。年龄较大、患有慢性阻塞性肺疾病和恶性肿瘤与死亡率相关。
芽生菌病相关住院治疗可能导致不良后果，这突出表明仍需关注芽生菌病的早期检测和治疗以及疾病趋势监测。
