Royer Cole, Owens Matthew, Wysong Kenrick, Madrid Michael, Moreau Katrina
University of Vermont, Department of Biomedical and Health Sciences, Burlington, VT, United States.
University of Vermont Medical Center, Department of Pathology and Laboratory Medicine, Burlington, VT, United States.
IDCases. 2024 Dec 25;39:e02139. doi: 10.1016/j.idcr.2024.e02139. eCollection 2025.
infections are classified as dimorphic fungal infections commonly seen geographically throughout the Mississippi and Ohio River Valleys, St. Laurence Seaways, as well as the Canadian providences of Ontario Manitoba, and Saskatchewan. Although primarily endemic in the Midwestern United States, there has been a rise in cases throughout New England. Factors that could contribute to this rise of blastomycosis include a changing climate, increasing use of immunosuppressive medications as well as a greater recognition of this disease. Initial presentation of blastomycosis follows the inhalation of fungal spores which can cause flu-like symptoms or mimic acute pneumonia. Blastomycosis can also present as a disseminated infection through extrapulmonary spread in both immunocompromised and immunocompetent hosts and cases present at similar rates within the population. Here we present a case of disseminated blastomycosis in a patient from New England with no reported pre-existing risk factors. The patient developed blastomycosis osteomyelitis in the left elbow which prompted surgical intervention as well as a 12-month regimen of voriconazole therapy. This case outlines the need to adopt better surveillance practices for blastomycosis in non-endemic areas as well as highlights the imperative role of healthcare staff in implementing proper reporting measures to track the spread of blastomycosis.
感染被归类为双相真菌感染,常见于密西西比河和俄亥俄河流域、圣劳伦斯航道以及加拿大安大略省、曼尼托巴省和萨斯喀彻温省等地。尽管主要在美国中西部地区流行,但新英格兰地区的病例也有所增加。可能导致芽生菌病病例增加的因素包括气候变化、免疫抑制药物使用增加以及对该疾病的认识提高。芽生菌病的初始表现是吸入真菌孢子后出现类似流感的症状或类似急性肺炎的症状。芽生菌病也可通过肺外传播在免疫功能低下和免疫功能正常的宿主中表现为播散性感染,且在人群中的发病率相似。在此,我们报告一例来自新英格兰地区的播散性芽生菌病病例,该患者无既往报道的危险因素。患者左肘部发生芽生菌性骨髓炎,促使进行手术干预以及为期12个月的伏立康唑治疗方案。该病例强调了在非流行地区对芽生菌病采取更好监测措施的必要性,同时也凸显了医护人员在实施适当报告措施以追踪芽生菌病传播方面的重要作用。