G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science, 159 Prospect 100-letiya Vladivostoka, Vladivostok 690022, Russia.
Faculty of Biology and Biotechnology, National Research University Higher School of Economics, 13/4 Myasnitskaya str., Moscow 117997, Russia.
Mar Drugs. 2023 Aug 27;21(9):470. doi: 10.3390/md21090470.
The carotenoids mixture (MC) isolated from the starfish contains more than 50% astaxanthin, 4-6% each zeaxanthine and lutein, and less pharmacologically active components such as free fatty acids and their glycerides. Astaxanthin, the major component of MC, belongs to the xanthophyll class of carotenoids, and is well known for its antioxidant properties. In this work, in vitro and in vivo studies on the biological activity of MC were carried out. The complex was shown to exhibit anti-inflammatory, anti-allergic and cancer-preventive activity, without any toxicity at a dose of 500 mg/kg. MC effectively improves the clinical picture of the disease progressing, as well as normalizing the cytokine profile and the antioxidant defense system in the in vivo animal models of inflammatory diseases, namely: skin carcinogenesis, allergic contact dermatitis (ACD) and systemic inflammation (SI). In the skin carcinogenesis induced by 7,12-dimethylbenzanthracene, the incidence of papillomas was decreased 1.5 times; 1% MC ointment form in allergic contact dermatitis showed an 80% reduced severity of pathomorphological skin manifestations. Obtained results show that MC from starfish is an effective remedy for the treatment and prevention of inflammatory processes.
从海星中分离得到的类胡萝卜素混合物（MC）含有超过 50%的虾青素、4-6%的玉米黄质和叶黄素，以及较少的具有药理活性的成分，如游离脂肪酸及其甘油酯。MC 的主要成分虾青素属于叶黄素类胡萝卜素，因其抗氧化特性而广为人知。在这项工作中，对 MC 的生物学活性进行了体外和体内研究。该复合物表现出抗炎、抗过敏和预防癌症的活性，在 500mg/kg 的剂量下没有任何毒性。MC 可有效改善疾病进展的临床情况，并使炎症性疾病的体内动物模型中的细胞因子谱和抗氧化防御系统正常化，即：皮肤癌变、过敏性接触性皮炎（ACD）和全身性炎症（SI）。在 7,12-二甲基苯并蒽诱导的皮肤癌变中，乳头状瘤的发病率降低了 1.5 倍；1%的 MC 软膏形式在过敏性接触性皮炎中表现出 80%减轻的皮肤病理表现严重程度。获得的结果表明，来自海星的 MC 是治疗和预防炎症过程的有效药物。
