Balaban Yucesan Fulya, Demir Eda Nur, Ozer Yaman Serap, Orem Asım, Dokuz Murat Busra, Bilgin Busra
Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
Department of Nutrition and Dietetics, Institute of Health Sciences, Marmara University, 34854 Istanbul, Turkey.
Metabolites. 2023 Sep 17;13(9):1019. doi: 10.3390/metabo13091019.
We hypothesized that the consumption of a 3-day standard diet (SD) prior to the oral fat tolerance test (OFTT), used to evaluate postprandial lipemia, may counteract the undesirable effects of individual dietary habits on the test results. The OFTT was applied to 22 healthy adults (11 females and 11 males), after their habitual diets (HDs) and following the consumption of a 3-day SD (45-60% energy from carbohydrate, 20-35% from fat, and 10-20% from protein). Plasma triglyceride (TG) concentrations were measured during fasting and at the fourth hour of the OFTT. A 3-day SD significantly reduced fasting and fourth-hour TG concentrations and delta TG values by 10%, 12.8%, and 22.7%, respectively. Decreases were observed in fasting and fourth-hour TG and delta TG values following the 3-day SD compared to the HD in subjects with fasting TG concentrations between 89 and 180 mg/dL ( = 0.062, = 0.018, and 0.047, respectively). As a result, the consumption of a 3-day standardized diet prior to the OFTT may be useful to eliminate the false positive or negative effects of individual dietary habits on test results and to correctly identify individuals who should be administered the OFTT.
我们假设，在用于评估餐后血脂异常的口服脂肪耐量试验（OFTT）之前食用3天标准饮食（SD），可能会抵消个体饮食习惯对测试结果的不良影响。对22名健康成年人（11名女性和11名男性）进行了OFTT，分别在其习惯饮食（HD）后以及食用3天SD（碳水化合物提供45 - 60%的能量、脂肪提供20 - 35%的能量、蛋白质提供10 - 20%的能量）之后进行。在空腹时以及OFTT的第4小时测量血浆甘油三酯（TG）浓度。3天SD显著降低了空腹和第4小时的TG浓度以及TG变化值，分别降低了10%、12.8%和22.7%。在空腹TG浓度为89至180 mg/dL的受试者中，与HD相比，3天SD后空腹和第4小时的TG以及TG变化值均有所下降（分别为 = 0.062、 = 0.018和0.047）。因此，在OFTT之前食用3天标准化饮食可能有助于消除个体饮食习惯对测试结果的假阳性或阴性影响，并正确识别应接受OFTT的个体。
