Adeola Adedapo O, Clermont-Paquette Adryanne, Piekny Alisa, Naccache Rafik
Department of Chemistry and Biochemistry and the Centre for NanoScience Research, Concordia University, Montreal, QC, H4B 1R6, Canada.
Quebec Centre for Advanced Materials, Department of Chemistry and Biochemistry, Concordia University, Montreal, QC, H4B 1R6, Canada.
Nanotechnology. 2023 Oct 16;35(1). doi: 10.1088/1361-6528/acfdaf.
Carbon dots (CDs) have garnered significant interest for their potential use in multiple applications due to their size, fluorescent properties, high photostability, low toxicity and biocompatibility. CDs can be tailored for specific needs, as they can be synthesized with diverse precursors and techniques for functionalization. Since the applications of CDs are rapidly expanding, this review highlights recent developments in this burgeoning field. Specifically, we describe advances in CD synthesis tailored for applications that include pH and temperature sensing, biochemical analysis, and bioimaging. We also discuss various challenges and practical solutions that will drive CD-based research forward. Challenges include the lack of standardized synthesis and purification methods for CDs, the lack of clarity regarding their mechanism of action, and procedural flaws in their applications. In conclusion, we provide recommendations for collaboration among disciplines to bridge existing knowledge gaps and address the key challenges required for CDs to be fully commercialized.
碳点（CDs）因其尺寸、荧光特性、高光稳定性、低毒性和生物相容性，在多种应用中的潜在用途而备受关注。碳点可以根据特定需求进行定制，因为它们可以用多种前驱体和功能化技术合成。由于碳点的应用正在迅速扩展，本综述重点介绍了这个新兴领域的最新进展。具体而言，我们描述了为pH和温度传感、生化分析及生物成像等应用量身定制的碳点合成进展。我们还讨论了各种挑战及切实可行的解决方案，这些将推动基于碳点的研究向前发展。挑战包括缺乏碳点标准化的合成和纯化方法、其作用机制尚不明确以及应用过程存在缺陷。总之，我们为跨学科合作提供建议，以弥合现有知识差距，并应对碳点全面商业化所需的关键挑战。
