Andre Mickensone, Lau Lee-Seng, Pokharel Marissa D, Ramelow Julian, Owens Florida, Souchak Joseph, Akkaoui Juliet, Ales Evan, Brown Harry, Shil Rajib, Nazaire Valeria, Manevski Marko, Paul Ngozi P, Esteban-Lopez Maria, Ceyhan Yasemin, El-Hage Nazira
Herbert Wertheim College of Medicine, Biomedical Sciences Program Florida International University, Miami, FL 33199, USA.
Biology (Basel). 2023 Sep 21;12(9):1267. doi: 10.3390/biology12091267.
SARS-CoV-2, the virus that causes COVID-19, is prone to mutations and the generation of genetic variants. Since its first outbreak in 2019, SARS-CoV-2 has continually evolved, resulting in the emergence of several lineages and variants of concern (VOC) that have gained more efficient transmission, severity, and immune evasion properties. The World Health Organization has given these variants names according to the letters of the Greek Alphabet, starting with the Alpha (B.1.1.7) variant, which emerged in 2020, followed by the Beta (B.1.351), Gamma (P.1), Delta (B.1.617.2), and Omicron (B.1.1.529) variants. This review explores the genetic variation among different VOCs of SARS-CoV-2 and how the emergence of variants made a global impact on the pandemic.
导致 COVID-19 的病毒 SARS-CoV-2 易于发生突变并产生基因变体。自 2019 年首次爆发以来，SARS-CoV-2 不断进化，导致出现了几个谱系和令人担忧的变体（VOC），这些变体具有更强的传播效率、致病性和免疫逃逸特性。世界卫生组织根据希腊字母表中的字母为这些变体命名，从 2020 年出现的 Alpha（B.1.1.7）变体开始，随后是 Beta（B.1.351）、Gamma（P.1）、Delta（B.1.617.2）和 Omicron（B.1.1.529）变体。本综述探讨了 SARS-CoV-2 不同 VOC 之间的基因变异，以及变体的出现如何对全球大流行产生影响。
