Bologa Emilia, Stoleriu Simona, Nica Irina, Tărăboanță Ionuț, Georgescu Andrei, Matei Ruxandra Ilinca, Andrian Sorin
Faculty of Dental Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 16 Universitatii Str., 700115 Iași, Romania.
Faculty of Medicine and Pharmacy, University of Oradea, 1st December Sq., 410068 Oradea, Romania.
Biomedicines. 2023 Sep 5;11(9):2464. doi: 10.3390/biomedicines11092464.
There are two main methods used for dentin hypersensitivity (DH) treatment: dentinal tubule occlusion and blockage of nerve activity. Dentifrices are the most common vehicles for active ingredients used for DH treatment. The aim of this study was to evaluate the efficacy of three toothpastes on dentinal tubule occlusion, mineral acquisition, and dentin hardness. Forty human dentin disks were submerged in 40% citric acid for 30 s and then exposed to tooth brushing for 2 min twice a day for 14 days using three toothpastes: Dontodent Sensitive (group 1), Dr. Wolff's Biorepair (group 2), and Sensodyne Repair and Protect (group 3). In the control group (group 4), the samples were brushed with water. All of the samples were evaluated using scanning electron microscopy (SEM), energy-dispersive X-ray (EDX), and Vickers dentin hardness determination. On SEM images, the degree of dentinal tubule occlusion was assessed using a five-grade scale. The mean score values in groups 1-4 were 3.60 ± 0.69, 2.20 ± 0.91, 2.30 ± 1.16, and 5.00 ± 0.00, significantly higher in study groups when compared to the control group (Kruskal Wallis test < 0.05). EDX evaluation showed significantly higher calcium and phosphorus concentrations in groups 1 and 3 when compared to control group d. The mean values of Vickers dentin hardness numbers in groups 1-4 were 243.03 ± 10.014, 327.38 ± 56.65, 260.29 ± 37.69, and 225.83 ± 29.93, respectively. No statistically significant results were obtained when comparing the hardness mean values in groups (Kruskal-Wallis statistical test, = 0.372 > 0.05). All three toothpastes tested demonstrated significant occlusion of dentinal tubules. Dontodent Sensitive and Sensodyne Repair and Protect toothpastes enhanced the calcium and phosphorus content of the dentin surface. None of the toothpastes increased dentin hardness as a result of mineral acquisition.
用于治疗牙本质过敏症（DH）的主要方法有两种：封闭牙本质小管和阻断神经活动。牙膏是用于DH治疗的活性成分最常见的载体。本研究的目的是评估三种牙膏对牙本质小管封闭、矿物质摄取和牙本质硬度的功效。将40个人类牙本质圆盘浸泡在40%的柠檬酸中30秒，然后使用三种牙膏：Dontodent Sensitive（第1组）、沃尔夫博士生物修复牙膏（第2组）和舒适达修复防护牙膏（第3组），每天刷牙两次，每次2分钟，持续14天。在对照组（第4组）中，样本用水刷牙。所有样本均使用扫描电子显微镜（SEM）、能量色散X射线（EDX）和维氏牙本质硬度测定进行评估。在SEM图像上，使用五级量表评估牙本质小管的封闭程度。第1 - 4组的平均得分值分别为3.60±0.69、2.20±0.91、2.30±1.16和5.00±0.00，与对照组相比，研究组的得分值显著更高（Kruskal Wallis检验<0.05）。EDX评估显示，与对照组d相比，第1组和第3组的钙和磷浓度显著更高。第1 - 4组的维氏牙本质硬度值平均值分别为243.03±10.014、327.38±56.65、260.29±37.69和225.83±29.93。比较各组硬度平均值时未获得统计学上的显著结果（Kruskal - Wallis统计检验，=0.372>0.05）。所测试的三种牙膏均显示出对牙本质小管的显著封闭。Dontodent Sensitive牙膏和舒适达修复防护牙膏提高了牙本质表面的钙和磷含量。没有一种牙膏因矿物质摄取而增加牙本质硬度。
