Department of Restorative Dentistry, Dental School, Shahed University of Medical Sciences, Italy St, Tehran, Iran.
Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Shahid Fahmideh St, Hamadan, Iran.
Clin Oral Investig. 2022 Oct;26(10):6061-6078. doi: 10.1007/s00784-022-04639-y. Epub 2022 Jul 25.
Bioactive glass and hydroxyapatite are biocompatible materials used as an adjunct to various dental materials. The present study aimed to evaluate the occlusion effects of bioactive glasses and hydroxyapatite on dental tubules.
We searched the PubMed/Medline, Embase, and Web of Science databases for the relevant records. The methodological quality of the studies was assessed by an accepted quality assessment tool.
From the electronic databases, 372 articles were retrieved. After evaluating the records, 35 in vitro studies were included. The studies revealed a low risk of bias. The primary outcomes from bioactive glass studies demonstrated the potential efficacy of both bioactive glass and hydroxyapatite in dentin tubule occlusion compared to the control.
The current systematic review showed that bioactive glass and hydroxyapatite could effectively occlude the dentinal tubules. Thus, desensitizing agents containing bioactive glass and hydroxyapatite can be used to manage dentin hypersensitivity (DH). However, long-term follow-up clinical trials are required in the future before definitive recommendations can be made.
This work achieved a satisfactorily systematic review for assessing desensitizing agents containing bioactive glass and hydroxyapatite in dentine hypersensitivity treatments recommended for clinical practice and research.
生物活性玻璃和羟基磷灰石是生物相容性材料，可用作各种牙科材料的辅助材料。本研究旨在评估生物活性玻璃和羟基磷灰石对牙本质小管的封闭效果。
我们在 PubMed/Medline、Embase 和 Web of Science 数据库中检索了相关记录。采用公认的质量评估工具评估研究的方法学质量。
从电子数据库中检索到 372 篇文章。在评估记录后，纳入了 35 项体外研究。这些研究显示出低偏倚风险。生物活性玻璃研究的主要结果表明，与对照组相比，生物活性玻璃和羟基磷灰石在牙本质小管封闭方面均具有潜在的疗效。
本系统评价显示，生物活性玻璃和羟基磷灰石可有效封闭牙本质小管。因此，含有生物活性玻璃和羟基磷灰石的脱敏剂可用于治疗牙本质过敏症（DH）。然而，未来需要进行长期的随访临床试验，才能得出明确的建议。
本研究成功进行了一项系统评价，评估了含有生物活性玻璃和羟基磷灰石的脱敏剂在牙本质过敏症治疗中的应用，为临床实践和研究提供了参考。
