Cardiology Department, University Clinical Hospital of Santiago de Compostela, 15706 Santiago de Compostela, Spain.
Centro de Investigación Biomédica Cardiovascular en Red (CIBERCV), Institute of Health Carlos III, C/Monforte de Lemos 3-5, Pabellón 11, Planta 0, 28029 Madrid, Spain.
Int J Mol Sci. 2023 Sep 13;24(18):14045. doi: 10.3390/ijms241814045.
This study aims to determine the predictive value of the soluble suppression of tumorigenicity 2 (sST2) biomarker in atrial fibrillation (AF) recurrence. This prospective, observational study included patients with AF referred for electrical cardioversion (ECV) or pulmonary vein isolation (PVI) procedures. Baseline characteristics were collected, and sST2 was determined at baseline and at 3 and 6 months of follow-up. sST2 was determined at baseline in a matched control group. Left atrial voltage mapping was performed in patients undergoing PVI. The sST2 maximal predictive capacity of AF recurrence was at the 3-month FU in the cohort of patients undergoing ECV with respect to 6-month AF recurrence with an AUC of 0.669, a cut-off point of 15,511 pg/mL, a sensitivity of 60.97%, and a specificity of 69.81%. The ROC curve of the sST2 biomarker at baseline and 3 months in the cohort of patients undergoing PVI showed AUCs of 0.539 and 0.490, respectively. The logistic regression model identified the rhythm (AF) and the sST2 biomarker at 3 months as independent factors for recurrence at 6 months in the ECV cohort. In the logistic regression model, sST2 was not an independent factor for recurrence at 6 months of follow-up in the PVI cohort. In patients who underwent ECV, sST2 values at 3 months may provide utility to predict AF recurrence at 6 months of follow-up. In patients who underwent PVI, sST2 had no value in predicting AF recurrence at 6 months of follow-up.
本研究旨在确定可溶性肿瘤抑制因子 2（sST2）生物标志物在心房颤动（AF）复发中的预测价值。这项前瞻性观察性研究纳入了因电复律（ECV）或肺静脉隔离（PVI）而接受治疗的 AF 患者。收集基线特征，并在基线和随访 3 个月和 6 个月时测定 sST2。在接受 PVI 的患者中进行了左心房电压测绘。在接受 ECV 的患者队列中，sST2 在 3 个月 FU 时对 6 个月 AF 复发的最大预测能力优于 6 个月 FU，AUC 为 0.669，截断值为 15511 pg/ml，灵敏度为 60.97%，特异性为 69.81%。在接受 PVI 的患者队列中，sST2 生物标志物在基线和 3 个月时的 ROC 曲线 AUC 分别为 0.539 和 0.490。逻辑回归模型确定节律（AF）和 3 个月时的 sST2 标志物是 ECV 队列中 6 个月时复发的独立因素。在逻辑回归模型中，sST2 不是 PVI 队列中 6 个月随访时复发的独立因素。在接受 ECV 的患者中，3 个月时的 sST2 值可能有助于预测 6 个月的 AF 复发。在接受 PVI 的患者中，sST2 对 6 个月随访时的 AF 复发无预测价值。
