Witkowska Justyna, Borowski Tomasz, Sowińska Agnieszka, Choińska Emilia, Moszczyńska Dorota, Morgiel Jerzy, Sobiecki Jerzy, Wierzchoń Tadeusz
Faculty of Materials Science and Engineering, Warsaw University of Technology, 02-507 Warsaw, Poland.
Pathology Department, Children's Memorial Health Institute, 04-730 Warsaw, Poland.
Materials (Basel). 2023 Sep 6;16(18):6086. doi: 10.3390/ma16186086.
The present study elucidates the impact of glow discharge oxidation within a low-temperature plasma environment on the bioactivity characteristics of an NiTi shape memory alloy. The properties of the produced surface layers, such as structure (TEM observations), surface morphology (SEM observations), chemical and phase composition (EDS and XRD measurements), wettability (optical gonimeter), and the biological response of osteoblasts and platelets to the oxidized surface compared with the NiTi alloy without a surface layer are presented. The presented surface modification of the NiTi shape memory alloy, achieved through oxidizing in a low-temperature plasma environment, led to the creation of a continuous surface layer composed of nanocrystalline titanium oxide TiO (rutile). The findings obtained from this study provide evidence that the oxidized layer augments the bioactivity of the shape memory alloy. This augmentation was substantiated through the spontaneous biomimetic deposition of apatite from a simulated body fluid (SBF) solution. Furthermore, the modified surface exhibited improved osteoblast proliferation, and enhanced platelet adhesion and activation. This proposed surface modification strategy holds promise as a prospective solution to enhance the biocompatibility and bioactivity of NiTi shape memory alloy intended for prolonged use in bone implant applications.
本研究阐明了低温等离子体环境中的辉光放电氧化对镍钛形状记忆合金生物活性特性的影响。展示了所产生表面层的特性，如结构（透射电子显微镜观察）、表面形态（扫描电子显微镜观察）、化学和相组成（能谱和X射线衍射测量）、润湿性（光学测角仪），以及与无表面层的镍钛合金相比，成骨细胞和血小板对氧化表面的生物学反应。通过在低温等离子体环境中氧化实现的镍钛形状记忆合金表面改性，导致形成了由纳米晶二氧化钛TiO（金红石）组成的连续表面层。本研究获得的结果证明氧化层增强了形状记忆合金的生物活性。这种增强通过在模拟体液（SBF）溶液中磷灰石的自发仿生沉积得到证实。此外，改性表面表现出改善的成骨细胞增殖以及增强的血小板粘附和活化。这种提出的表面改性策略有望成为一种前瞻性解决方案，以提高用于骨植入应用中长期使用的镍钛形状记忆合金的生物相容性和生物活性。
