墨西哥基于医疗机构场所和年龄组对抗菌药物耐药性及碳青霉烯酶编码基因的主动监测：来自INVIFAR网络的结果
Active Surveillance of Antimicrobial Resistance and Carbapenemase-Encoding Genes According to Sites of Care and Age Groups in Mexico: Results from the INVIFAR Network.
作者信息
Rojas-Larios Fabian, Martínez-Guerra Bernardo Alfonso, López-Jácome Luis Esaú, Bolado-Martínez Enrique, Vázquez-Larios María Del Rosario, Velázquez-Acosta María Del Consuelo, Romero-Romero Daniel, Mireles-Dávalos Christian Daniel, Quintana-Ponce Sandra, Feliciano-Guzmán José Manuel, Pérez-Hernandez José Miguel, Correa-León Yoselin Paola, López-Gutiérrez Eduardo, Rodriguez-Noriega Eduardo, González-Díaz Esteban, Choy-Chang Elena Victoria, Mena-Ramírez Juan Pablo, Monroy-Colín Víctor Antonio, Ponce-de-León-Garduño Alfredo, Alcaraz-Espejel Margarita, Avilés-Benítez Laura Karina, Quintanilla-Cazares Luís Javier, Ramírez-Alanís Eloisa, Barajas-Magallón Juan Manuel, Padilla-Ibarra Cecilia, Ballesteros-Silva Maria Bertha, Atanacio-Sixto Noe Antonio, Morales-de-la-Peña Cecilia Teresita, Galindo-Méndez Mario, Pérez-Vicelis Talía, Jacobo-Baca Guillermo, Moreno-Méndez Martha Irene, Mora-Pacheco María de la Luz, Gutiérrez-Brito Maricruz, Sánchez-Godínez Xochitl Yadira, Navarro-Vargas Norberta Vianey, Mercado-Bravo Luz Elena, Delgado-Barrientos Alejandro, Santiago-Calderón María Asunción, López-Ovilla Ismelda, Molina-Chavarria Alejandro, Rincón-Zuno Joaquín, Franco-Cendejas Rafael, Miranda-Mauricio Sandra, Márquez-Avalos Isabel Cristina, López-García Maribel, Duarte-Miranda Lizbeth Soraya, Cetina-Umaña Carlos Miguel, Barroso-Herrera-Y-Cairo Irma Elena, López-Moreno Laura Isabel, Garza-González Elvira
机构信息
Laboratorio de Microbiología, Hospital Regional Universitario de Colima, Colima 28040, Mexico.
Departamento de Infectología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México 14080, Mexico.
出版信息
Pathogens. 2023 Sep 7;12(9):1144. doi: 10.3390/pathogens12091144.
We analyzed the antimicrobial resistance (AMR) data of 6519 clinical isolates of ( = 3985), ( = 775), ( = 163), ( = 781), ( = 124), and ( = 691) from 43 centers in Mexico. AMR assays were performed using commercial microdilution systems (37/43) and the disk diffusion susceptibility method (6/43). The presence of carbapenemase-encoding genes was assessed using PCR. Data from centers regarding site of care, patient age, and clinical specimen were collected. According to the site of care, the highest AMR was observed in , , and isolates from ICU patients. In contrast, in , higher AMR was observed in isolates from hospitalized non-ICU patients. According to age group, the highest AMR was observed in the ≥60 years age group for , , and , and in the 19-59 years age group for and . According to clinical specimen type, a higher AMR was observed in , , and isolates from blood specimens. The most frequently detected carbapenemase-encoding gene in was (84%).
我们分析了来自墨西哥43个中心的6519株临床分离菌的抗菌药物耐药性（AMR）数据，这些分离菌包括大肠埃希菌（n = 3985）、肺炎克雷伯菌（n = 775）、鲍曼不动杆菌（n = 163）、铜绿假单胞菌（n = 781）、金黄色葡萄球菌（n = 124）和肠球菌（n = 691）。AMR检测使用商业微量稀释系统（43个中心中的37个）和纸片扩散法药敏试验（43个中心中的6个）。使用PCR评估碳青霉烯酶编码基因的存在情况。收集了各中心关于护理地点、患者年龄和临床标本的数据。根据护理地点，在重症监护病房（ICU）患者的大肠埃希菌、肺炎克雷伯菌和鲍曼不动杆菌分离株中观察到最高的AMR。相比之下，在铜绿假单胞菌中，住院非ICU患者的分离株中观察到更高的AMR。根据年龄组，在≥60岁年龄组的大肠埃希菌、肺炎克雷伯菌和鲍曼不动杆菌中以及在19 - 59岁年龄组的铜绿假单胞菌和金黄色葡萄球菌中观察到最高的AMR。根据临床标本类型，血液标本中的大肠埃希菌、肺炎克雷伯菌和鲍曼不动杆菌分离株中观察到更高的AMR。在鲍曼不动杆菌中最常检测到的碳青霉烯酶编码基因是blaOXA - 23（84%）。
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