Cotton Adam C, Scorr Laura, McDonald William, Comella Cynthia, Perlmutter Joel S, Goetz Christopher G, Jankovic Joseph, Marsh Laura, Factor Stewart, Jinnah H A
Department of Neurology Emory University School of Medicine Atlanta Georgia USA.
Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta Georgia USA.
Mov Disord Clin Pract. 2023 Aug 3;10(9):1399-1403. doi: 10.1002/mdc3.13827. eCollection 2023 Sep.
Assessing disease severity can be performed using either clinician-rated scales (CRS) or patient-rated outcome (PRO) tools. These two measures frequently demonstrate poor correlations.
To determine if the correlation between a CRS and PRO for motor features of cervical dystonia (CD) improves by accounting for non-motor features.
Subjects with CD (N = 209) were evaluated using a CRS (Toronto Western Spasmodic Torticollis Rating Scale, TWSTRS) and a PRO (Cervical Dystonia Impact Profile, CDIP-58).
Linear regression revealed a weak correlation between the two measures, even when considering only the motor subscales of each. The strength of this relationship improved with a regression model that included non-motor symptoms of pain, depression, and disability.
These results argue that the results of motor assessments in a PRO for CD cannot be fully appreciated without simultaneous assessment of non-motor co-morbidities. This conclusion might apply to other disorders, especially those with frequent non-motor co-morbidities.
评估疾病严重程度可使用临床医生评定量表（CRS）或患者报告结局（PRO）工具。这两种测量方法常常显示出较差的相关性。
通过考虑非运动特征，确定CRS与PRO在颈部肌张力障碍（CD）运动特征方面的相关性是否得到改善。
使用CRS（多伦多西部痉挛性斜颈评定量表，TWSTRS）和PRO（颈部肌张力障碍影响概况，CDIP - 58）对209例CD患者进行评估。
线性回归显示，即使仅考虑两者的运动子量表，这两种测量方法之间的相关性也较弱。当回归模型纳入疼痛、抑郁和残疾等非运动症状时，这种关系的强度有所改善。
这些结果表明，在CD的PRO中，如果不同时评估非运动合并症，运动评估结果就无法得到充分理解。这一结论可能适用于其他疾病，尤其是那些经常伴有非运动合并症的疾病。
