新型噬菌体 IME183 的基因组特征，该噬菌体感染荚膜型 K2 的肺炎克雷伯菌。
Genomic characterization of the novel bacteriophage IME183, infecting Klebsiella pneumoniae of capsular type K2.
机构信息
College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China.
Center for Clinical Laboratory, The Affiliated Taian City Central Hospital of Qingdao University, Taian, 271000, Shandong, China.
出版信息
Arch Virol. 2023 Sep 29;168(10):261. doi: 10.1007/s00705-023-05873-9.
Klebsiella pneumoniae causes a wide range of serious and life-threatening infections. Klebsiella phage IME183, isolated from hospital sewage, exhibited lytic activity against K. pneumoniae of capsular type K2. Transmission electron microscopy revealed that phage IME183 has a head with a diameter of 50 nm and a short tail. Its genome is 41,384 bp in length with a GC content of 52.92%. It is predicted to contain 50 open reading frames (ORFs). The results of evolutionary analysis suggest that phage IME183 should be considered a member of a new species in the genus Przondovirus.
肺炎克雷伯菌可引起广泛的严重且危及生命的感染。从医院污水中分离到的肠杆菌噬菌体 IME183 对荚膜型 K2 的肺炎克雷伯菌具有裂解活性。透射电子显微镜显示噬菌体 IME183 头部直径为 50nm，短尾。其基因组长 41384bp，GC 含量为 52.92%。预测含有 50 个开放阅读框 (ORFs)。进化分析结果表明，噬菌体 IME183 应被视为 Przondovirus 属的一个新种成员。
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