Nicoll J M, Treuren B, Acharya P A, Ahlen K, James M
Anesth Analg. 1986 Dec;65(12):1324-8.
The present study was conducted in 100 patients receiving retrobulbar block for ophthalmic surgery to compare the efficacy of local anesthetic solutions with and without hyaluronidase. All patients received 3.5 ml of a mixture of 3 ml of 0.5% bupivacaine and 2 ml of 2% lidocaine. Seventy-five international units of hyaluronidase were diluted in 5 ml of the local anesthetic mixture and used for 50 of the blocks. The remainder did not receive hyaluronidase. A consistently better motor blockade was achieved with hyaluronidase (P less than 0.001 at 10, 15, and 20 min). This finding has not been conclusively demonstrated before.
本研究对100例接受眼科手术球后阻滞的患者进行，以比较含透明质酸酶和不含透明质酸酶的局部麻醉溶液的疗效。所有患者均接受3.5 ml由3 ml 0.5%布比卡因和2 ml 2%利多卡因组成的混合液。75国际单位的透明质酸酶用5 ml局部麻醉混合液稀释，并用于50次阻滞。其余患者未接受透明质酸酶。使用透明质酸酶可始终获得更好的运动阻滞效果（在10、15和20分钟时P值均小于0.001）。这一发现此前尚未得到确凿证实。
