Beam T R, Galask R P, Friedhoff L T, Platt T B, Leitz M A
Antimicrob Agents Chemother. 1986 Sep;30(3):505-7. doi: 10.1128/AAC.30.3.505.
The concentrations of aztreonam in human tissues obtained during surgery were measured after a single 2-g intravenous dose. The average concentration in the skeletal muscle, atrial appendage, lung, sternum, pericardial fluid, endometrium, myometrium, fallopian tube, and ovary varied from 3 to 33 micrograms/g (or microgram/ml). These concentrations significantly exceed the MIC for 90% of strains for most members of the family Enterobacteriaceae.
单次静脉注射2克氨曲南后，测量了手术中获取的人体组织中氨曲南的浓度。骨骼肌、心耳、肺、胸骨、心包液、子宫内膜、子宫肌层、输卵管和卵巢中的平均浓度在3至33微克/克（或微克/毫升）之间。这些浓度显著超过了肠杆菌科大多数成员90%菌株的最低抑菌浓度。
