在胸外科和妇科手术期间获取的人体组织中的氨曲南浓度。
Aztreonam concentrations in human tissues obtained during thoracic and gynecologic surgery.
作者信息
Beam T R, Galask R P, Friedhoff L T, Platt T B, Leitz M A
出版信息
Antimicrob Agents Chemother. 1986 Sep;30(3):505-7. doi: 10.1128/AAC.30.3.505.
Abstract
The concentrations of aztreonam in human tissues obtained during surgery were measured after a single 2-g intravenous dose. The average concentration in the skeletal muscle, atrial appendage, lung, sternum, pericardial fluid, endometrium, myometrium, fallopian tube, and ovary varied from 3 to 33 micrograms/g (or microgram/ml). These concentrations significantly exceed the MIC for 90% of strains for most members of the family Enterobacteriaceae.
摘要
单次静脉注射2克氨曲南后，测量了手术中获取的人体组织中氨曲南的浓度。骨骼肌、心耳、肺、胸骨、心包液、子宫内膜、子宫肌层、输卵管和卵巢中的平均浓度在3至33微克/克（或微克/毫升）之间。这些浓度显著超过了肠杆菌科大多数成员90%菌株的最低抑菌浓度。
相似文献
1
Aztreonam concentrations in human tissues obtained during thoracic and gynecologic surgery.在胸外科和妇科手术期间获取的人体组织中的氨曲南浓度。
Antimicrob Agents Chemother. 1986 Sep;30(3):505-7. doi: 10.1128/AAC.30.3.505.
2
[Diffusion of aztreonam in the tissues and biological fluids of the female genital tract].[氨曲南在女性生殖道组织和生物流体中的扩散]
Pathol Biol (Paris). 1986 May;34(5):339-41.
3
Aztreonam concentration in abdominal tissues and bile.氨曲南在腹部组织和胆汁中的浓度。
Antimicrob Agents Chemother. 1986 Jun;29(6):1101-3. doi: 10.1128/AAC.29.6.1101.
4
[Clinical effect of aztreonam in infections in obstetrics and gynecology].氨曲南在妇产科感染中的临床疗效
Jpn J Antibiot. 1985 Dec;38(12):3527-30.
5
[Preclinical and clinical studies on aztreonam in the field of obstetrics and gynecology].氨曲南在妇产科领域的临床前及临床研究
Jpn J Antibiot. 1985 Dec;38(12):3542-60.
6
[Fundamental and clinical studies on aztreonam in the field of obstetrics and gynecology].氨曲南在妇产科领域的基础与临床研究
Jpn J Antibiot. 1985 Dec;38(12):3634-44.
7
[In vitro activity and clinical evaluation of aztreonam in the field of obstetrics and gynecology].氨曲南在妇产科领域的体外活性及临床评价
Jpn J Antibiot. 1985 Dec;38(12):3629-33.
8
[Preclinical and clinical studies on aztreonam in obstetrics and gynecology].氨曲南在妇产科的临床前及临床研究
Jpn J Antibiot. 1985 Dec;38(12):3520-6.
9
[Study on transfer of aztreonam into female genital organs].
Jpn J Antibiot. 1985 Dec;38(12):3666-73.
10
[Fundamental and clinical studies on aztreonam in obstetrics and gynecology].氨曲南在妇产科的基础与临床研究
Jpn J Antibiot. 1985 Dec;38(12):3704-10.
引用本文的文献
1
Tissue Distribution and Pharmacokinetic Characteristics of Aztreonam Based on Multi-Species PBPK Model.基于多物种生理药代动力学（PBPK）模型的氨曲南组织分布及药代动力学特征
Pharmaceutics. 2025 Jun 6;17(6):748. doi: 10.3390/pharmaceutics17060748.
2
Evaluation of a New Culture-Based AtbFinder Test-System Employing a Novel Nutrient Medium for the Selection of Optimal Antibiotics for Critically Ill Patients with Polymicrobial Infections within 4 h.评估一种基于培养的新型AtbFinder检测系统，该系统采用新型营养培养基，可在4小时内为患有多重微生物感染的重症患者选择最佳抗生素。
Microorganisms. 2021 May 4;9(5):990. doi: 10.3390/microorganisms9050990.
3
Filamentous bacteriophages are associated with chronic lung infections and antibiotic resistance in cystic fibrosis.丝状噬菌体与囊性纤维化患者肺部慢性感染和抗生素耐药性有关。
Sci Transl Med. 2019 Apr 17;11(488). doi: 10.1126/scitranslmed.aau9748.
4
Clinical pharmacokinetics of aztreonam. An update.氨曲南的临床药代动力学。最新进展。
Clin Pharmacokinet. 1994 Feb;26(2):99-106. doi: 10.2165/00003088-199426020-00003.
5
Clinical pharmacokinetics of aztreonam.
Clin Pharmacokinet. 1988 Mar;14(3):148-55. doi: 10.2165/00003088-198814030-00003.
本文引用的文献
1
Single-dose pharmacokinetics of the monobactam azthreonam (SQ 26,776) in healthy subjects.健康受试者中单环β-内酰胺类氨曲南（SQ 26,776）的单剂量药代动力学。
Antimicrob Agents Chemother. 1982 Jun;21(6):944-9. doi: 10.1128/AAC.21.6.944.
2
Azthreonam (SQ 26,776), a synthetic monobactam specifically active against aerobic gram-negative bacteria.氨曲南（SQ 26,776），一种对需氧革兰氏阴性菌有特效的合成单环β-内酰胺抗生素。
Antimicrob Agents Chemother. 1982 Jan;21(1):85-92. doi: 10.1128/AAC.21.1.85.
3
Pharmacokinetics and tissue penetration of azthreonam.氨曲南的药代动力学及组织穿透性。
Antimicrob Agents Chemother. 1982 Dec;22(6):969-71. doi: 10.1128/AAC.22.6.969.
4
High-pressure liquid chromatographic analysis of aztreonam in sera and urine.血清和尿液中氨曲南的高效液相色谱分析
Antimicrob Agents Chemother. 1983 Jun;23(6):852-6. doi: 10.1128/AAC.23.6.852.
5
Penetration of aztreonam into cerebrospinal fluid of patients with and without inflamed meninges.氨曲南在有或没有脑膜炎症的患者脑脊液中的穿透情况。
Antimicrob Agents Chemother. 1984 Nov;26(5):730-3. doi: 10.1128/AAC.26.5.730.
6
Effect of hemodialysis and peritoneal dialysis on aztreonam pharmacokinetics.
Kidney Int. 1984 Sep;26(3):308-18. doi: 10.1038/ki.1984.174.
7
Biliary excretion of aztreonam in patients with biliary tract disease.氨曲南在胆道疾病患者中的胆汁排泄情况。
Antimicrob Agents Chemother. 1984 Mar;25(3):358-61. doi: 10.1128/AAC.25.3.358.
8
Tissue penetration and half-life of cefonicid.头孢尼西的组织穿透性和半衰期。
Rev Infect Dis. 1984 Nov-Dec;6 Suppl 4:S821-8. doi: 10.1093/clinids/6.supplement_4.s821.
9
Pharmacokinetic study of moxalactam in patients undergoing gynecologic operations.莫西拉坦在妇科手术患者中的药代动力学研究。
Am J Obstet Gynecol. 1984 Dec 1;150(7):882-4. doi: 10.1016/0002-9378(84)90467-8.
10
Aztreonam concentrations in human prostatic tissue.氨曲南在人体前列腺组织中的浓度。
Antimicrob Agents Chemother. 1984 Jul;26(1):20-1. doi: 10.1128/AAC.26.1.20.
Zotero 插件