Prince A M, Gershon R K
Yale J Biol Med. 1979 Mar-Apr;52(2):159-67.
In a study of apparently normal, healthy Korean Army recruits performed in 1962, we found that 42 of 1,906 screened subjects had elevations of their serum glutamic pyruvate transaminase. Liver biopsies were obtained from 32 of these subjects and 9 of these had a "novel" antigen present, which reacted specifically with a convalescent serum from a case of serum hepatitis. We have recently tested frozen serum obtained from 8/9 of these cases and found that all 8 had HBsAg in their serum which, in some cases, persisted for at least three months. We reviewed the histological specimens from the original 32 cases using newly defined criteria: 18 were diagnosed as chronic active hepatitis and the 8 HbsAg positive cases with the "novel" antigen were in this group. In four of these cases the lesion appeared to progress to cirrhosis during a 3--4 month follow-up period. Since none of the cases had a prior history of hepatitis and no symptoms developed during the follow-up period, our findings emphasize the significance of chronic hepatitis B virus carrier state in the etiology of cryptogenic cirrhosis.
在1962年对看似正常、健康的韩国陆军新兵进行的一项研究中，我们发现，在1906名接受筛查的受试者中，有42人的血清谷丙转氨酶升高。从其中32名受试者身上获取了肝活检样本，其中9人存在一种“新型”抗原，该抗原与一例血清性肝炎患者的恢复期血清发生特异性反应。我们最近检测了其中8/9例患者的冷冻血清，发现所有8例患者血清中均有乙肝表面抗原（HBsAg），在某些情况下，该抗原至少持续存在了三个月。我们使用新定义的标准复查了最初32例患者的组织学标本：18例被诊断为慢性活动性肝炎，8例HBsAg阳性且带有“新型”抗原的病例也在这一组中。在其中4例患者中，病变在3至4个月的随访期内似乎发展为肝硬化。由于所有病例均无肝炎病史，且在随访期间未出现症状，我们的研究结果强调了慢性乙肝病毒携带状态在隐源性肝硬化病因中的重要性。
