Department of Immunology and Regenerative Biology, Weizmann Institute of Science, 7610001 Rehovot, Israel; Department of Molecular Neuroscience, Weizmann Institute of Science, 7610001 Rehovot, Israel.
Department of Immunology and Regenerative Biology, Weizmann Institute of Science, 7610001 Rehovot, Israel; Department of Molecular Neuroscience, Weizmann Institute of Science, 7610001 Rehovot, Israel.
Trends Genet. 2023 Dec;39(12):908-923. doi: 10.1016/j.tig.2023.09.001. Epub 2023 Sep 30.
Mammalian genomes are pervasively transcribed into different noncoding (nc)RNA classes, each one with its own hallmarks and exceptions. Some of them are nested into each other, such as host genes for small nucleolar RNAs (snoRNAs), which were long believed to simply act as molecular containers strictly facilitating snoRNA biogenesis. However, recent findings show that noncoding snoRNA host genes (ncSNHGs) display features different from those of 'regular' long ncRNAs (lncRNAs) and, more importantly, they can exert independent and unrelated functions to those of the encoded snoRNAs. Here, we review and summarize past and recent evidence that ncSNHGs form a defined subclass among the plethora of lncRNAs, and discuss future research that can further elucidate their biological relevance.
哺乳动物基因组广泛转录成不同的非编码 (nc) RNA 类别，每一种都有其自身的特点和例外。其中一些 RNA 嵌套在一起，例如小核仁 RNA (snoRNA) 的宿主基因，长期以来被认为只是作为分子容器，严格促进 snoRNA 的生物发生。然而，最近的发现表明，非编码 snoRNA 宿主基因 (ncSNHGs) 表现出不同于“常规”长非编码 RNA (lncRNAs) 的特征，更重要的是，它们可以发挥与编码 snoRNAs 无关的独立功能。在这里，我们回顾和总结了过去和最近的证据，表明 ncSNHGs 在众多 lncRNAs 中形成了一个明确的亚类，并讨论了未来的研究可以进一步阐明它们的生物学相关性。
