Meistrup-Larsen K I, Mogensen H H, Helweg-Larsen K, Permin H, Andersen V, Rygaard J, Sørensen H
Acta Otolaryngol Suppl. 1979;360:204-7. doi: 10.3109/00016487809123517.
Adenoid tissue was obtained at operation from 27 children admitted for adenoidectomy and from 6 controls. The occurrence of cells with cytoplasmic immunoglobulin was studied semiquantitatively by immunofluorescence microscopy of tissue sections, by which localization, number of cells and class of immunoglobulin were determined. No differences were found between patients and controls. Cells isolated from adenoid tissue were compared with mononuclear leukocytes obtained from the blood. More B lymphocytes were found in the tissue, in particular IgM-carrying cells. This was more pronounced in the patient group. Cells were stimulated in culture with polyclonal activators and microbial antigens. The response of adenoid lymphocytes to Haemophilus influenzae (HI) was high in 7/27 patients; all patients in whom throat culture was positive for HI were low responders.
手术时从27名因腺样体切除术入院的儿童及6名对照者获取腺样体组织。通过组织切片免疫荧光显微镜检查对细胞质免疫球蛋白阳性细胞的发生率进行半定量研究，确定其定位、细胞数量及免疫球蛋白类别。患者与对照者之间未发现差异。将从腺样体组织分离的细胞与从血液中获取的单核白细胞进行比较。在组织中发现更多B淋巴细胞，尤其是携带IgM的细胞。这在患者组中更为明显。用多克隆激活剂和微生物抗原在培养中刺激细胞。27例患者中有7例腺样体淋巴细胞对流感嗜血杆菌（HI）反应较高；所有HI咽培养阳性的患者反应较低。
