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限制热量的饮食干预对睡眠剥夺肥胖患者体重减轻和肠道微生物多样性的影响。

Effects of a calorie-restricted dietary intervention on weight loss and gut microbiota diversity in obese patients with sleep deprivation.

机构信息

Department of Endocrinology, Huai'an Hospital Affiliated to Xuzhou Medical University and Huai'an Second People's Hospital, Huai'an, 223002, Jiangsu, China.

Department of Cardiothoracic Surgery, Hospital Affiliated to Nanjing Medical University and Huai'an First People's Hospital, Huai'an, 223001, Jiangsu, China.

出版信息

Eat Weight Disord. 2023 Oct 4;28(1):80. doi: 10.1007/s40519-023-01609-5.

DOI:10.1007/s40519-023-01609-5
PMID:37792102
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10550869/
Abstract

OBJECTIVES

This study aimed to investigate the effects of a calorie-restricted dietary (CRD) intervention on weight and gut microbiota diversity in obese patients with sleep deprivation (SD).

METHODS

Twenty obese patients were divided into a sleep deprivation group (SD group, n = 10) and a nonsleep deprivation group (NSD group, n = 10), both of which underwent a CRD intervention for 12 weeks. Measurement of anthropometric parameters, biochemical examinations and gut microbiota detection were performed at baseline and at the end of week 12. Mi Smart Bands 1 (Standard Option) were used to monitor sleep and exercise.

RESULTS

(1) The CRD intervention improved body weight (BW), waist circumference (WC), blood pressure (BP), basal metabolic rate (BMR), body fat content (BFC), and insulin resistance index (HOMA-IR) in all obese patients. (2) In the NSD group, BW, BFC, VFA (visceral fat area), BMR and total cholesterol (TC) were significantly reduced after the CRD intervention (P < 0.05). (3) The alpha diversity of the gut microbiota remained unchanged after the intervention in the two groups. (4) There was a negative correlation between Mollicutes and BMR in the NSD group.

CONCLUSIONS

The effects of a CRD intervention weaken on weight loss and the metabolism of blood lipids may be weakened by SD. The abundance of Mollicutes bacteria may be related to weight loss after a CRD intervention in obese patients.

LEVEL OF EVIDENCE

III, prospective cohort study.

摘要

目的

本研究旨在探讨限制热量饮食（CRD）干预对睡眠剥夺（SD）肥胖患者体重和肠道微生物多样性的影响。

方法

将 20 名肥胖患者分为睡眠剥夺组（SD 组，n=10）和非睡眠剥夺组（NSD 组，n=10），两组均接受 CRD 干预 12 周。在基线和第 12 周末测量人体测量参数、生化检查和肠道微生物检测。使用 Mi Smart Bands 1（标准选项）监测睡眠和运动。

结果

（1）CRD 干预改善了所有肥胖患者的体重（BW）、腰围（WC）、血压（BP）、基础代谢率（BMR）、体脂含量（BFC）和胰岛素抵抗指数（HOMA-IR）。（2）在 NSD 组，CRD 干预后 BW、BFC、VFA（内脏脂肪面积）、BMR 和总胆固醇（TC）显著降低（P<0.05）。（3）两组干预后肠道微生物多样性无变化。（4）NSD 组中 Mollicutes 与 BMR 呈负相关。

结论

SD 可能会削弱 CRD 干预对体重减轻和血脂代谢的作用。CRD 干预后肥胖患者 Mollicutes 细菌的丰度可能与体重减轻有关。

证据水平

III，前瞻性队列研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf4/10550869/d86a94ad1b4c/40519_2023_1609_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf4/10550869/9569c751e2c6/40519_2023_1609_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf4/10550869/b49000c4469a/40519_2023_1609_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf4/10550869/49972d150a55/40519_2023_1609_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf4/10550869/2ebe0a960dc1/40519_2023_1609_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf4/10550869/d86a94ad1b4c/40519_2023_1609_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf4/10550869/9569c751e2c6/40519_2023_1609_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf4/10550869/b49000c4469a/40519_2023_1609_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf4/10550869/49972d150a55/40519_2023_1609_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf4/10550869/2ebe0a960dc1/40519_2023_1609_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf4/10550869/d86a94ad1b4c/40519_2023_1609_Fig5_HTML.jpg

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