Cole Lyndsey D, Hammershaimb E Adrianne, Liang Yuanyuan, Hendrich Megan A, Das Dhiman, Petrin Robert, Campbell James D, O'Leary Sean, Cataldi Jessica R
Section of Infectious Diseases, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.
Section of Rheumatology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.
Open Forum Infect Dis. 2023 Sep 21;10(10):ofad476. doi: 10.1093/ofid/ofad476. eCollection 2023 Oct.
Little is known about parental awareness of multisystem inflammatory syndrome in children (MIS-C), a rare but severe sequela of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Via a nationally representative, cross-sectional survey of US parents conducted via Ipsos KnowledgePanel from October to November 2021, we used bivariate and multivariable analyses to describe and identify demographic variables associated with parental knowledge of and attitudes toward MIS-C and to examine associations with perceived coronavirus disease 2019 (COVID-19) severity and susceptibility.
Response rate was 64.2% (3230/5034). Thirty-two percent of respondents had heard of MIS-C. After adjustment, higher educational level (compared to high school degree; some college: odds ratio [OR], 2.00 [95% confidence interval {CI}, 1.44-2.77]; bachelor's degree or higher: OR, 3.14 [95% CI, 2.26-4.35]), being a healthcare worker (OR, 1.82 [95% CI, 1.37-2.42]), having a child with a chronic medical condition (OR, 1.62 [95% CI, 1.22-2.14]), and experience with more severe COVID-19 (OR, 1.46 [95% CI, 1.14-1.86]) were associated with MIS-C awareness. Respondents with a child aged 12-17 years were less likely to be aware of MIS-C compared to those without (OR, 0.78 [95% CI, .63-.96]), as were male respondents (OR, 0.56 [95% CI, .46-.69]) and respondents aged 18-34 years (OR, 0.72 [95% CI, .54-.94]) compared to those aged 35-44 years. Awareness of MIS-C was associated with higher perceived COVID-19 severity and susceptibility (regression coefficients, 0.18 [95% CI, .10-.25], < .001; 0.19 [95% CI, .11-.28], < .001, respectively).
This survey highlights the need to increase parental awareness of MIS-C. Future studies should explore how education regarding MIS-C as a complication of SARS-CoV-2 infection could improve understanding of pediatric disease severity and susceptibility.
儿童多系统炎症综合征（MIS-C）是严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染的一种罕见但严重的后遗症，关于父母对其的认知情况知之甚少。
通过益普索知识面板于2021年10月至11月对美国父母进行的一项具有全国代表性的横断面调查，我们使用双变量和多变量分析来描述和识别与父母对MIS-C的认知及态度相关的人口统计学变量，并检验与感知的2019冠状病毒病（COVID-19）严重程度和易感性的关联。
回复率为64.2%（3230/5034）。32%的受访者听说过MIS-C。调整后，较高的教育水平（与高中学历相比；部分大学学历：比值比[OR]，2.00[95%置信区间{CI}，1.44 - 2.77]；学士学位或更高：OR，3.14[95%CI，2.26 - 4.35]）、身为医护人员（OR，1.82[95%CI，1.37 - 2.42]）、有患有慢性疾病的孩子（OR，1.62[95%CI，1.22 - 2.14]）以及有更严重COVID-19经历（OR，1.46[95%CI，1.14 - 1.86]）与对MIS-C的认知相关。与没有12至17岁孩子的受访者相比，有该年龄段孩子的受访者知晓MIS-C的可能性较小（OR，0.78[95%CI，0.63 - 0.96]），男性受访者（OR，0.56[95%CI，0.46 - 0.69]）以及18至34岁的受访者（OR，0.72[95%CI，0.54 - 0.94]）与35至44岁的受访者相比也是如此。对MIS-C的认知与更高的COVID-19严重程度感知和易感性相关（回归系数分别为0.18[95%CI，0.10 - 0.25]，P <.001；0.19[95%CI，0.11 - 0.28]，P <.001）。
这项调查凸显了提高父母对MIS-C认知的必要性。未来的研究应探索将MIS-C作为SARS-CoV-2感染并发症的教育如何能增进对儿科疾病严重程度和易感性的理解。
