Phillips D H, Hewer A, Grover P L
Carcinogenesis. 1986 Dec;7(12):2071-5. doi: 10.1093/carcin/7.12.2071.
DNA from normal human bone marrow mononuclear and non-mononuclear cells was analysed by 32P-post-labelling for the presence of aromatic adducts. Ten out of 10 individuals showed the presence of adducts at levels of 1-9 adducts per 10(8) nucleotides that were not detected in four samples of human foetal bone marrow. Inter-individual variations in the patterns of these presumed aromatic adducts were observed. Similar adducts were also present in the DNA of peripheral white blood cells of both smokers and non-smokers, although at lower levels than in bone marrow. The data suggest that the adducts result from environmental exposure to an as-yet-unidentified genotoxic agent or agents.
通过³²P后标记法分析正常人骨髓单核细胞和非单核细胞的DNA，以检测芳香族加合物的存在。10名个体中有10名显示出加合物的存在，每10⁸个核苷酸中有1 - 9个加合物，而在4份人类胎儿骨髓样本中未检测到这些加合物。观察到这些推测的芳香族加合物模式存在个体间差异。吸烟者和非吸烟者外周血白细胞的DNA中也存在类似的加合物，不过水平低于骨髓中的加合物。数据表明，这些加合物是环境暴露于一种或多种尚未确定的基因毒性剂所致。
