生物标志物在儿童及发育中胎儿环境风险研究中的应用。
Application of biologic markers to studies of environmental risks in children and the developing fetus.
作者信息
Whyatt R M, Perera F P
机构信息
Columbia University School of Public Health, New York, NY 10032, USA.
出版信息
Environ Health Perspect. 1995 Sep;103 Suppl 6(Suppl 6):105-10. doi: 10.1289/ehp.95103s6105.
Abstract
Young children and the developing fetus may be more susceptible to effects of environmental toxicants than adults due to differential exposure patterns and developmental immaturities. Biologic markers offer the potential of quantitative dosimeters of biologic dose and/or indices of biologic effect associated with fetal/childhood exposures. They can facilitate evaluation of interindividual variability in response and the magnitude of age-related susceptibilities. Thus far, biologic markers have not been widely used in developmental epidemiology of environmental exposures. Research by our group and others has seen elevations in biologic markers in samples from children and fetal tissue associated with a spectrum of environmental exposures, including tobacco smoke (active and passive), ambient pollution, and dietary contaminants. Studies also suggest that biologic markers can provide powerful dosimeters for investigating reproductive effects. Validation of biologic markers offering the greatest promise for developmental epidemiology is needed.
摘要
由于接触模式不同和发育不成熟，幼儿和发育中的胎儿可能比成年人更容易受到环境毒物的影响。生物标志物有可能成为生物剂量的定量剂量计和/或与胎儿/儿童接触相关的生物效应指标。它们有助于评估个体反应的变异性以及与年龄相关的易感性程度。到目前为止，生物标志物尚未在环境暴露的发育流行病学中广泛应用。我们小组和其他机构的研究发现，儿童样本和胎儿组织中的生物标志物水平升高与一系列环境暴露有关，包括烟草烟雾（主动和被动）、环境污染和饮食污染物。研究还表明，生物标志物可为调查生殖效应提供有力的剂量计。需要对在发育流行病学中最具前景的生物标志物进行验证。
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