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Effect of age on the pharmacokinetics of diazepam given in conjunction with spinal anesthesia.

作者信息

Kanto J, Mäenpää M, Mäntylä R, Sellman R, Valovirta E

出版信息

Anesthesiology. 1979 Aug;51(2):154-9. doi: 10.1097/00000542-197908000-00013.

DOI:10.1097/00000542-197908000-00013
PMID:378033
Abstract
摘要

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1
Effect of age on the pharmacokinetics of diazepam given in conjunction with spinal anesthesia.年龄对与脊髓麻醉联合使用时地西泮药代动力学的影响。
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2
Simultaneous determination of diazepam and its metabolies N-desmethyldiazepam, oxydiazepam and oxazepam in plasma and urine of man and dog by means of high-performance liquid chromatography.采用高效液相色谱法同时测定人及犬血浆和尿液中地西泮及其代谢物N-去甲基地西泮、奥沙西泮和氯氮䓬。
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Determination of diazepam and nordazepam in milk and plasma in the presence of oxazepam and temazepam.在存在奥沙西泮和替马西泮的情况下，测定牛奶和血浆中的地西泮和去甲地西泮。
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Rapid gas chromatographic measurement of diazepam and its metabolites desmethyldiazepam, oxazepam, and 3-hydroxydiazepam (temazepam) in small samples of plasma.血浆小样本中地西泮及其代谢产物去甲基地西泮、奥沙西泮和3-羟基地西泮（替马西泮）的快速气相色谱测定
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Excretion of diazepam and its metabolites in human milk during withdrawal from combination high dose diazepam and oxazepam.在停用高剂量地西泮和奥沙西泮联合用药期间，地西泮及其代谢产物在人乳中的排泄情况。
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引用本文的文献

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The influence of old age and poloxamer-407 on the hepatic disposition of diazepam in the isolated perfused rat liver.年龄和泊洛沙姆 407 对离体大鼠肝中地西泮肝处置的影响。
Pharmacology. 2012;90(5-6):233-41. doi: 10.1159/000341724. Epub 2012 Sep 19.
2
Regional anaesthesia in the elderly: a clinical guide.老年患者区域麻醉：临床指南
Drugs Aging. 2004;21(14):895-910. doi: 10.2165/00002512-200421140-00001.
3
Disposition of oxazepam in relation to age, sex, and cigarette smoking.
Klin Wochenschr. 1981 Aug 17;59(16):899-903. doi: 10.1007/BF01721923.
4
[Benzodiazepines: significance of kinetics for therapy].[苯二氮䓬类药物：动力学在治疗中的意义]
Klin Wochenschr. 1983 Mar 1;61(5):213-24. doi: 10.1007/BF01496127.
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Benzodiazepines: a summary of pharmacokinetic properties.苯二氮䓬类药物：药代动力学特性概述
Br J Clin Pharmacol. 1981;11 Suppl 1(Suppl 1):11S-16S. doi: 10.1111/j.1365-2125.1981.tb01833.x.
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Clobazam kinetics in the elderly.老年人中氯巴占的动力学
Br J Clin Pharmacol. 1981 Nov;12(5):631-6. doi: 10.1111/j.1365-2125.1981.tb01281.x.
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Effect of age and sex on disposition of desmethyldiazepam formed from its precursor clorazepate.年龄和性别对由其前体氯氮䓬形成的去甲基地西泮处置的影响。
Psychopharmacology (Berl). 1981;75(2):193-7. doi: 10.1007/BF00432186.
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Hepatic drug metabolism and aging.肝脏药物代谢与衰老
Clin Pharmacokinet. 1990 Nov;19(5):359-89. doi: 10.2165/00003088-199019050-00002.
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The problems and pitfalls of NSAID therapy in the elderly (Part II).老年人非甾体抗炎药治疗的问题与陷阱（第二部分）
Drugs Aging. 1991 May;1(3):212-27. doi: 10.2165/00002512-199101030-00005.
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Clinical pharmacokinetics of anxiolytics and hypnotics in the elderly. Therapeutic considerations (Part II).老年人中抗焦虑药和催眠药的临床药代动力学。治疗考量（第二部分）
Clin Pharmacokinet. 1991 Oct;21(4):262-73. doi: 10.2165/00003088-199121040-00003.