Unit of Hereditary Digestive Tract Tumours, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Unit of Bioinformatics and Biostatistics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Int J Colorectal Dis. 2023 Oct 7;38(1):249. doi: 10.1007/s00384-023-04531-5.
Colorectal adenomatous polyposis is characterized by the onset of tens to thousands of adenomas in the colorectal epithelium and, if not treated, leads to a lifetime increased risk of developing colorectal cancer compared to the general population. Thus, prophylactic surgery is recommended. This study aims to investigate the quality of life of colorectal adenomatous polyposis patients following prophylactic surgery and indirectly compares these findings with those of healthy adults of the normative sample.
All patients who underwent prophylactic surgery for polyposis and were in follow-up at the hereditary digestive tract tumors outpatient department of our institute were eligible for the study. The Short Form-36 questionnaire and 21 ad hoc items were used at the time of clinical evaluation.
A total of 102 patients were enrolled. For the SF-36 domains, mean values ranged from 64.18 for vitality to 88.49 for physical functioning, with the highest variability for role-physical limitations; the minimum value of functioning was reached for role-physical limitations, role-emotional limitations, and social functioning. The maximum value of functioning was reached for role-emotional limitations (73.96%) and role-physical limitations (60.42%). In total, 48.96% and 90.63% of patients reported no fecal or urinary incontinence episodes, respectively; 69.79% of patients did not have problems in work/school resumption or the personal sexual sphere.
Quality of life following prophylactic surgery for these patients seems to be good when indirectly compared to HP-normative samples'. Young adult patients appear to quickly manage and adapt to changes in bowel functioning. A minority of patients may experience social and sexual issues.
结直肠腺瘤性息肉病的特征是在结直肠上皮中出现数十到数千个腺瘤，如果不治疗，与普通人群相比，终生患结直肠癌的风险增加。因此，建议进行预防性手术。本研究旨在调查预防性手术后结直肠腺瘤性息肉病患者的生活质量，并间接地将这些发现与健康成年人的参考样本进行比较。
所有在我院遗传性消化道肿瘤门诊接受息肉预防性手术并在随访中的患者均符合本研究的条件。在临床评估时使用了简短形式 36 问卷和 21 项特定项目。
共纳入 102 例患者。对于 SF-36 领域，平均值范围从活力的 64.18 到身体功能的 88.49，角色身体限制的变异性最大；身体功能受限、角色情感限制和社会功能达到最低功能值。角色情感限制（73.96%）和角色身体限制（60.42%）达到了最高的功能值。总的来说，分别有 48.96%和 90.63%的患者报告没有粪便或尿失禁发作；69.79%的患者在恢复工作/学业或个人性生活方面没有问题。
与 HP 参考样本间接比较，这些患者预防性手术后的生活质量似乎良好。年轻成年患者似乎很快就能管理和适应肠道功能的变化。少数患者可能会出现社交和性问题。
