食管癌中自噬与微小RNA的相互作用
The Crosstalk Between Autophagy and MicroRNAs in Esophageal Carcinoma:
作者信息
Gorjizadeh Neda, Poudineh Sahar, Barghgir Behnaz, Eghbali Mohammadreza, Sarlak Alireza, Poudineh Maryam
机构信息
Department of Internal Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran 2 School of Medicine, Mashhad Azad University, Mashhad, Iran.
School of Medicine, Mashhad Azad University, Mashhad, Iran.
出版信息
Galen Med J. 2023 May 23;12:e2903. doi: 10.31661/gmj.v12i.2903. eCollection 2023.
Esophageal cancer (EC) is considered one of the most prevalent and aggressive malignancies worldwide, with a variety of molecular alterations thought to contribute to its incidence, development, progression, and invasion. However, the exact underlying mechanism has not been elucidated. Autophagy is a highly conserved degradative and recycling process that can function with a dual role in either the progression or the treatment of EC. Since microRNAs (miRNAs) are described as upstream regulators capable of controlling both oncogenic pathways and autophagic flux, the present study has aimed to review the crosstalk between autophagy and miRNAs and the potential perspective of these mechanisms in EC prevention and treatment.
食管癌（EC）被认为是全球最常见且侵袭性最强的恶性肿瘤之一，多种分子改变被认为与其发生、发展、进展及侵袭有关。然而，确切的潜在机制尚未阐明。自噬是一种高度保守的降解和再循环过程，在食管癌的进展或治疗中可发挥双重作用。由于微小RNA（miRNA）被描述为能够控制致癌途径和自噬通量的上游调节因子，本研究旨在综述自噬与miRNA之间的相互作用以及这些机制在食管癌预防和治疗中的潜在前景。
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