Mary Arulandhu Clara, Ireen Christopher, Vijayalakshmi Periyasamy, Indhu Sabapathy, Divyabharathi Sekar, Felix Kulandaisamy Suregka, Daisyrani Viyagulasamy, Rajalakshmi Manikkam
Department of Biotechnology and Bioinformatics, Holy Cross College (Autonomous), Tiruchirappalli, Tamil Nadu, India.
DBT-BIF Centre, Holy Cross College (Autonomous), Tiruchirappalli, Tamil Nadu, India.
Bioinformation. 2023 Mar 31;19(3):238-242. doi: 10.6026/97320630019238. eCollection 2023.
Due to their rising prevalence, diabetes and obesity were both classified as epidemics by the World Health Organization.The natural leaf essence of (), is used as herbal remedy for diabetes and obesity worldwide. However, the objective of the current research was to examine the effects of consuming commercially available porridge on both diabetes and obesity. The S. dulcis plants were collected and the essence was prepared in a traditional way. Phytochemical screening was carried out to identify the secondary metabolites present in the essence. The GC-MS analysis was carried out to identify the bioactive compounds present in the extracts. In order to understand the molecular interaction of identified compounds with selected target proteins from anti-diabetic, anti-oxidant, anti-obesity molecular docking studies was carried out. Results of this docking studies confirmed that identified compounds showed the strong interaction with all the selected target protein. Further experimental analysis is needed to confirm this activity.
由于糖尿病和肥胖症的患病率不断上升，它们都被世界卫生组织列为流行病。（）的天然叶精华在全球范围内被用作治疗糖尿病和肥胖症的草药。然而，当前研究的目的是检验食用市售的（此处原文缺失相关内容）粥对糖尿病和肥胖症的影响。采集了甜菊叶植物并以传统方式制备精华。进行了植物化学筛选以鉴定精华中存在的次生代谢物。进行了气相色谱 - 质谱分析以鉴定提取物中存在的生物活性化合物。为了了解已鉴定化合物与来自抗糖尿病、抗氧化、抗肥胖的选定靶蛋白的分子相互作用，进行了分子对接研究。该对接研究的结果证实，已鉴定的化合物与所有选定的靶蛋白都表现出强烈的相互作用。需要进一步的实验分析来证实这种活性。
