Xie Yuyan, Zhou Yang, Wang Jiale, Du Lijuan, Ren Yuanyuan, Liu Fang
Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, 150081, China.
Heliyon. 2023 Sep 5;9(9):e19799. doi: 10.1016/j.heliyon.2023.e19799. eCollection 2023 Sep.
Ferroptosis was first proposed in 2012, a new form of cell death. Autophagy plays a crucial role in cell clearance and maintaining homeostasis. Autophagy is involved in the initial step of ferroptosis under the action of histone elements such as NCOA4, RAB7A, and BECN1. Ferroptosis and autophagy are involved in tumor progression, treatment, and drug resistance in the tumor microenvironment. In this review, we described the mechanisms of ferroptosis, autophagy, and tumor and immunotherapy, respectively, and emphasized the relationship between autophagy-related ferroptosis and tumor.
铁死亡于2012年首次被提出，是一种新的细胞死亡形式。自噬在细胞清除和维持体内平衡中起关键作用。在NCOA4、RAB7A和BECN1等组蛋白元件的作用下，自噬参与铁死亡的起始步骤。铁死亡和自噬都参与肿瘤微环境中的肿瘤进展、治疗及耐药性。在本综述中，我们分别阐述了铁死亡、自噬以及肿瘤和免疫治疗的机制，并强调了自噬相关铁死亡与肿瘤之间的关系。
