Lampe K F
Annu Rev Pharmacol Toxicol. 1979;19:85-104. doi: 10.1146/annurev.pa.19.040179.000505.
Much progress in the areas of identification of active components and elucidation of the toxic mechanisms for the principal poisonous mushrooms has been made in the past decade. This affords a more rational approach to therapeutic management which has consequently resulted in a decrease in the morbidity and mortality associated with these species. However, the effectiveness of a large number of adjuvants for Amanita phalloides poisoning still needs critical laboratory evaluation. The current status of knowledge concerning the toxic potential and contituents of many mushroom species, including the gastroenteric irritants, is inadequate. The problem of geographic variation or genetic strain in the concentration of toxins of many species also requires further investigation. The recent awareness and interest in the pharmacology and toxicology of uncultivated mushrooms in North America and Great Britain should encourage continued active research.
在过去十年中，主要毒蘑菇活性成分的鉴定和毒性机制的阐明方面取得了很大进展。这为治疗管理提供了更合理的方法，从而降低了与这些物种相关的发病率和死亡率。然而，大量用于毒鹅膏中毒的佐剂的有效性仍需要严格的实验室评估。关于许多蘑菇物种的潜在毒性和成分，包括胃肠刺激物，目前的知识状况还不够充分。许多物种毒素浓度的地理变异或基因菌株问题也需要进一步研究。北美和英国最近对野生蘑菇药理学和毒理学的认识和兴趣应鼓励继续积极开展研究。
