Effect of probiotics on hematological parameters of male and female Wistar rats.

In the present study, the effect of probiotics on the hematology of Wistar rats was examined. Locally isolated MZ707748 (Pro 1) MZ710117 (Pro 2) MZ727611 (Pro 3), and MZ735961 (Pro 4) were used One strain of probiotic, 14 (Pro 5), was purchased commercially. Different groups were designed as G1, G2, G3, G4, and 5, G5/PC consisting only pro 5 and NC & 0 day were untreated. Different groups have different probiotics like G1 containing Pro 1 and Pro 2, G2 comprising Pro 3 and Pro 4, G3 containing Pro 2, Pro 3 and Pro 5, G4 having Pro 1-5, and G5 containing Pro 5. A complete count of blood, serum chemistry, fecal analysis, and histopathological examination of the thymus and liver were done. Statistical differences were seen in the complete blood count parameters (p < 0.05). No difference was observed in AST, ALT, bilirubin, albumin, IL-6, and IgA (p > 0.05) except for TP, creatinine, and globulin (p < 0.05). Fecal strains of probiotic groups were antibiotic-resistant. In males, OQ152020, OQ1519891, OQ152017, OQ152017, and OQ152019 were isolated from positive control, G1, G2, G3, and G4 respectively. In females, sp. OP800231, OQ151985, OP800267, OP800244, and OQ151988 were isolated from positive control, G1, G2, G3 and G4, respectively. It was concluded that all probiotic strains were safe to use and had beneficial effects on the hematology of Wistar rats.