Ingram D L, Dauncey M J
Horm Metab Res. 1986 Oct;18(10):677-9. doi: 10.1055/s-2007-1012405.
The effect of thyroid hormones on the reduction in resting metabolic rate by the beta-blocker propranolol has been investigated in young pigs. Oxygen consumption was measured 12 to 20 hr after the last meal in euthyroid and hypothyroid animals on a high or low level of energy intake. The increase in resting metabolic rate in animals on the high energy intake was reduced by propranolol in the euthyroid controls but not in those animals made hypothyroid by methimazole. Thus at least part of the action of propranolol to decrease diet-induced thermogenesis depends on its interaction with thyroid hormones.
在幼猪中研究了甲状腺激素对β受体阻滞剂普萘洛尔降低静息代谢率的影响。在能量摄入处于高或低水平的正常甲状腺和甲状腺功能减退动物中，于最后一餐12至20小时后测量耗氧量。在正常甲状腺的对照动物中，普萘洛尔降低了高能量摄入动物的静息代谢率升高，但在通过甲巯咪唑导致甲状腺功能减退的动物中则没有降低。因此，普萘洛尔降低饮食诱导的产热作用至少部分取决于其与甲状腺激素的相互作用。
